From NSAIDs to glucocorticoids and beyond

Sinniah, Ajantha and Yazid, Samia and Flower, Rod J. (2021) From NSAIDs to glucocorticoids and beyond. Cells, 10 (12). ISSN 2073-4409, DOI

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Our interest in inflammation and its treatment stems from ancient times. Hippocrates used willow bark to treat inflammation, and many centuries later, salicylic acid and its derivative aspirin's ability to inhibit cyclooxygenase enzymes was discovered. Glucocorticoids (GC) ushered in a new era of treatment for both chronic and acute inflammatory disease, but their potentially dangerous side effects led the pharmaceutical industry to seek other, safer, synthetic GC drugs. The discovery of the GC-inducible endogenous anti-inflammatory protein annexin A1 (AnxA1) and other endogenous proresolving mediators has opened a new era of anti-inflammatory therapy. This review aims to recapitulate the last four decades of research on NSAIDs, GCs, and AnxA1 and their anti-inflammatory effects.

Item Type: Article
Uncontrolled Keywords: Nonsteroidal anti-inflammatory drugs (NSAIDs); Glucocorticoids; Annexin A1; Inflammation
Subjects: Q Science > QH Natural history > QH426 Genetics
Divisions: Faculty of Medicine
Depositing User: Ms Zaharah Ramly
Date Deposited: 14 Apr 2022 00:55
Last Modified: 14 Apr 2022 00:55

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