Molecularly imprinted polymers-based DNA biosensors

Nawaz, Noman and Abu Bakar, Nor Kartini and Mahmud, Habibun Nabi Muhammad Ekramul and Jamaludin, Nazzatush Shimar (2021) Molecularly imprinted polymers-based DNA biosensors. Analytical Biochemistry, 630. ISSN 0003-2697, DOI

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In multiple biological processes, molecular recognition performs an integral role in detecting bio analytes. Molecular imprinted polymers (MIPs) are tailored sensing materials that can biomimic the biologic ligands and can detect specific target molecules selectively and sensitively. The formulation of molecularly imprinted polymers is followed by the formulation of a control termed as non-imprinted polymer (NIP), which, in the absence of a template, is commonly formulated to evaluate whether distinctive imprints have been produced for the template. Given the difficulties confronting bioanalytical researchers, it is inevitable that this strategy would come out as a central route of multidisciplinary studies to create extremely promising stable artificial receptors as a replacement or accelerate biological matrices. The ease of synthesis, low cost, capability to `tailor' recognition element for analyte molecules, and stability under harsh environments make MIPs promising candidates as a recognition tool for biosensing. Compared to biological systems, molecular imprinting techniques have several advantages, including high recognition ability, long-term durability, low cost, and robustness, allowing molecularly imprinted polymers to be employed in drug delivery, biosensor technology, and nanotechnology. Molecular imprinted polymer-based sensors still have certain shortcomings in determining biomacromolecules (nucleic acid, protein, lipids, and carbohydrates), considering the vast volume of the latest literature on biomicromolecules. These potential materials are still required to address a few weaknesses until gaining their position in recognition of biomacromolecules. This review aims to highlight the current progress in molecularly imprinted polymers (MIPs)-based sensors for the determination of deoxyribonucleic acid (DNA) or nucleobases.

Item Type: Article
Funders: University of Malaya Impact-Oriented Interdisciplinary Research Grant Programme (IIRG) (IIRG002A-19SAH)
Uncontrolled Keywords: Molecularly imprinted polymers; Biosensors; Conducting polymers; DNA; Nanocomposite
Subjects: Q Science > QD Chemistry
Q Science > QH Natural history > QH301 Biology
Divisions: Faculty of Science > Department of Chemistry
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 18 Mar 2022 04:06
Last Modified: 18 Mar 2022 04:06

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