Mechanical and fluidic analysis of hollow side-open and outer-grooved design of microneedles

Ahmad, Nur Farrahain Nadia and Nik Ghazali, Nik Nazri and Wong, Yew Hoong (2021) Mechanical and fluidic analysis of hollow side-open and outer-grooved design of microneedles. Materials Today Communications, 29. p. 102940. ISSN 2352-4928, DOI

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This paper presents a novel concept design for microneedles that can perform dual release patterns by utilizing outer grooves as a pathway for instant delivery, dissolving body microneedles which are loaded with stimuli-responsive nanocarriers for sustained delivery and a bore for extraction diagnosis purposes. ANSYS software is used to analyze the performance of the proposed design involving mechanical structural and mechanical-fluid dynamics analysis. The effect of various grooved designs on skin puncture performance on the tri-layer skin model has been investigated, and the presence of grooves can minimize contact interaction, leading to low insertion force. Then, instant delivery via the outer grooves, which involves open-channel and closed-channel, is studied (0.033 μl/min). For dissolution performance for limited and sustained source loading is investigated using analytical analysis. With a set extraction flow rate of about 0.0015 μl/min and a vacuum pressure of 10kPa, the bore design is optimized to minimize vortex formation. Lastly, the structural strength of the proposed microneedle is investigated by applying axial and transverse loads which show the generated stress is less than the material strength. Overall, simulation results confirm that the proposed microneedles can provide both sustained-instant release of insulin simultaneously and perform extraction with minimal vortex formation to provide precise sampling amount and avoid delay of fluid movement. This design has high potential to be used in developing a closed-loop system for transdermal insulin delivery and diagnosis, known as "artificial pancreas". © 2021 Elsevier Ltd

Item Type: Article
Funders: ‘Skim Latihan Akademik Muda’ (SLAM) from Universiti Teknologi Malaysia (UTM), Impact-Oriented Interdisciplinary Research Grant Programme ( IIRG018B-2019 ) from Universiti Malaya (UM), Malaysia
Uncontrolled Keywords: ANSYS simulation; Fluid dynamic; Insulin delivery; Mechanical dynamic; Microneedles; Structural
Subjects: T Technology > TJ Mechanical engineering and machinery
Divisions: Faculty of Engineering
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 29 Dec 2021 04:25
Last Modified: 29 Dec 2021 04:25

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