Leuconicines A−G and (−)-Eburnamaline, Biologically Active Strychnan and Eburnan Alkaloids fromLeuconotis

Gan, Chew Yan and Low, Yun Yee and Etoh, Tadahiro and Hayashi, Masahiko and Komiyama, Kanki and Kam, Toh Seok (2009) Leuconicines A−G and (−)-Eburnamaline, Biologically Active Strychnan and Eburnan Alkaloids fromLeuconotis. Journal of Natural Products, 72 (12). pp. 2098-2103. ISSN 0163-3864, DOI https://doi.org/10.1021/np900576b.

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Official URL: https://doi.org/10.1021/np900576b


Seven new indole alkaloids of the Strychnos type, leuconicines A-G (1-7), and a new eburnan alkaloid, (-)-eburnamaline (8), were isolated from the stem-bark extract of two Malayan Leuconotis species. The structures of these alkaloids were established using NMR and MS analysis and in the case of 8 also by partial synthesis. Alkaloids 1-5 reversed multidrug resistance in vincristine-resistant KB cells. © 2009 American Chemical Society and American Society of Pharmacognosy.

Item Type: Article
Uncontrolled Keywords: Drug Resistance, Multiple; Drug Screening Assays, Antitumor; Humans; Indole Alkaloids; KB Cells; Malaysia; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Plant Bark; Plant Stems; Stereoisomerism; Vincristine
Subjects: Q Science > Q Science (General)
Q Science > QD Chemistry
Divisions: Faculty of Science > Department of Chemistry
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 14 Dec 2020 05:34
Last Modified: 14 Dec 2020 05:34
URI: http://eprints.um.edu.my/id/eprint/25657

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