Aporphine alkaloids with in vitro antiplasmodial activity from the leaves of Phoebe tavoyana

Omar, Hanita and Fadaeinasab, Mehran and Taha, Hairin and Widyawaruyanti, Aty and Nafiah, Mohd Azlan and Rachmatiah, Tiah (2020) Aporphine alkaloids with in vitro antiplasmodial activity from the leaves of Phoebe tavoyana. Journal of Asian Natural Products Research, 22 (1). pp. 52-60. ISSN 1028-6020, DOI https://doi.org/10.1080/10286020.2018.1553958.

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Official URL: https://doi.org/10.1080/10286020.2018.1553958


One new aporphine named tavoyanine A (1), along with four known aporphines laetanine (2), roemerine (3), laurolitsine (4), and boldine (5), and one morphinandienone type sebiferine (6) were isolated from the leaves of Phoebe tavoyana (Meissn.) Hook f. (Lauraceae). The isolation was achieved by chromatographic techniques, and the structural elucidation was performed via spectral methods. This paper also reports the antiplasmodial activity of roemerine (3), laurolitsine (4), boldine (5), and sebiferine (6). The results showed that 3–6 have a potent inhibitory activity against the growth of Plasmodium falciparum 3D7 clone, with IC50 values of 0.89, 1.49, 1.65, and 2.76 µg/ml, respectively. © 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group.

Item Type: Article
Funders: PPP Grant (PV091/ 2011B) and BKP Grant (BKP069-2016) from University of Malaya
Uncontrolled Keywords: Phoebe tavoyana; Lauraceae; aporphine alkaloid; morphinandienone; antiplasmodial; Plasmodium falciparum
Subjects: Q Science > Q Science (General)
Q Science > QD Chemistry
Divisions: Centre for Foundation Studies in Science > Chemistry Division
Faculty of Science > Department of Chemistry
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 25 Aug 2020 08:40
Last Modified: 25 Aug 2020 08:40
URI: http://eprints.um.edu.my/id/eprint/25457

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