Microwave synthesis of hydroxyapatite encumbered with ascorbic acid intended for drug leaching studies

Padmanabhan, Varun Prasath and Kulandaivelu, Ravichandran and Santhana Panneer, Devendrapandi and Vivekananthan, S. and Sagadevan, Suresh and Lett, J. Anita (2020) Microwave synthesis of hydroxyapatite encumbered with ascorbic acid intended for drug leaching studies. Materials Research Innovations, 24 (3). pp. 171-178. ISSN 1432-8917, DOI https://doi.org/10.1080/14328917.2019.1624940.

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Official URL: https://doi.org/10.1080/14328917.2019.1624940


The characteristics properties of hydroxyapatite (HAP, Ca10 (PO4)6(OH) 2) namely, bioactivity, biocompatibility, osteoconductive and adsorption capacity can be tailored over wide assortments by governing the particle composition, particle dimensions, and structure. Pure hydroxyapatite (HAP) nanoparticles were synthesized by a simple straightforward approach using microwave irradiation method. The prepared HAP samples were studied for phase purity using X-ray diffractometer (XRD); functional group analysis using Fourier transform Infrared (FTIR) spectroscopy. Scanning electron microscopy (SEM) and Transmission electron microscopy (TEM) was used to examine the assembling of the HAP particles. These outcomes validate that shorter rod–like HAP particles can be organized by microwave irradiation technique. The synthesized HAP samples were loaded with ascorbic acid to analyze it’s in vitro drug release studies and its biocompatibility was confirmed by means of MTT assay using Saos-2 cell lines (Human Osteosarcoma Cell Line). © 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group.

Item Type: Article
Uncontrolled Keywords: HAP; Microwave method; nanorods; ascorbic acid; MTT assay
Subjects: Q Science > Q Science (General)
Q Science > QC Physics
Q Science > QD Chemistry
Divisions: Deputy Vice Chancellor (Research & Innovation) Office > Nanotechnology & Catalysis Research Centre
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 25 Aug 2020 03:17
Last Modified: 25 Aug 2020 03:17
URI: http://eprints.um.edu.my/id/eprint/25436

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