Efficient and Simultaneous Chitosan-Mediated Removal of 11 Mycotoxins from Palm Kernel Cake

Pirouz, Atena Abbasi and Selamat, Jinap and Iqbal, Shahzad Zafar and Samsudin, Nik Iskandar Putra (2020) Efficient and Simultaneous Chitosan-Mediated Removal of 11 Mycotoxins from Palm Kernel Cake. Toxins, 12 (2). p. 115. ISSN 2072-6651, DOI https://doi.org/10.3390/toxins12020115.

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Official URL: https://doi.org/10.3390/toxins12020115


Mycotoxins are an important class of pollutants that are toxic and hazardous to animal and human health. Consequently, various methods have been explored to abate their effects, among which adsorbent has found prominent application. Liquid chromatography tandem mass spectrometry (LC–MS/MS) has recently been applied for the concurrent evaluation of multiple mycotoxins. This study investigated the optimization of the simultaneous removal of mycotoxins in palm kernel cake (PKC) using chitosan. The removal of 11 mycotoxins such as aflatoxins (AFB1, AFB2, AFG1 and AFG2), ochratoxin A (OTA), zearalenone (ZEA), fumonisins (FB1 and FB2) and trichothecenes (deoxynivalenol (DON), HT-2 and T-2 toxin) from palm kernel cake (PKC) was studied. The effects of operating parameters such as pH (3–6), temperature (30–50 ◦C) and time (4–8 h) on the removal of the mycotoxins were investigated using response surface methodology (RSM). Response surface models obtained with R2 values ranging from 0.89–0.98 fitted well with the experimental data, except for the trichothecenes. The optimum point was obtained at pH 4, 8 h and 35 ◦C. The maximum removal achieved with chitosan for AFB1, AFB2, AFG1, AFG2, OTA, ZEA, FB1 and FB2 under the optimized conditions were 94.35, 45.90, 82.11, 84.29, 90.03, 51.30, 90.53 and 90.18%, respectively. © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

Item Type: Article
Funders: Ministry of Education Malaysia [grant number 6369114]
Uncontrolled Keywords: Chitosan; Detoxification; LC-MS/MS; Mycotoxins; Optimization
Subjects: Q Science > Q Science (General)
Q Science > QH Natural history
Divisions: Faculty of Science > Institute of Biological Sciences
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 18 Aug 2020 06:30
Last Modified: 18 Aug 2020 06:30
URI: http://eprints.um.edu.my/id/eprint/25397

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