Level and determinants of serum perfluoroalkyl acids (PFAAs) in a population in Klang Valley, Malaysia

Ramli, Mohd Redzuan and Yoneda, Minoru and Mohd, Mustafa Ali and Haron, Didi Erwandi Mohamad and Ahmad, Emmy Dayana (2020) Level and determinants of serum perfluoroalkyl acids (PFAAs) in a population in Klang Valley, Malaysia. International Journal of Hygiene and Environmental Health, 223 (1). pp. 179-186. ISSN 1438-4639, DOI https://doi.org/10.1016/j.ijheh.2019.09.005.

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Official URL: https://doi.org/10.1016/j.ijheh.2019.09.005


For decades, perfluoroalkyl acids (PFAAs) have been commonly used for industrial and commercial purposes due to their water- and stain-resistant properties. Persistent pollutants that contain PFAAs have been associated with adverse health effects in humans, and many studies have documented dietary intake, indoor air inhalation, and dermal contact as the potential routes for human exposure to PFAAs. The aim of this study was to assess the level of PFAAs in the serum samples of a general population in a specific region in Malaysia. Using 219 serum samples collected from residents of Klang Valley, Malaysia, the levels of nine PFAAs were analyzed using liquid chromatography-tandem mass spectrometry. In addition, questionnaire surveys on the dietary habits and lifestyles of the subjects were conducted. The results showed that PFAA concentrations of up to 32.57 ng/mL were detected in all serum samples. In 82.6% of the participants, at least seven PFAAs were detected in the serum samples, with perfluorooctanesulfonic acid being the predominant PFAA (median = 8.79 ng/mL). In the adjusted regression model, the concentrations of most PFAAs were higher in men than in women and positively correlated with age, although body mass index and smoking were not significantly associated with the serum PFAA concentrations. Taking into consideration the lifestyle variables, significant associations were found between nonstick cookware and perfluorononanoic acid, between dental floss and cosmetics and perfluorodecanoic acid (PFDA), and between leather sofa and perfluoroundecanoic acid (PFUnDA). Besides, consumption of beef was significantly associated with increased levels of serum PFUnDA, whereas consumption of lamb and chicken eggs was negatively associated with the serum levels of PFUnDA and PFDA, respectively. © 2019 Elsevier GmbH

Item Type: Article
Funders: Malaysian Government Agency Grant ( GA007-2013 )
Uncontrolled Keywords: Perfluoroalkyl acids; Biomonitoring; Dietary exposure; Serum; Malaysia
Subjects: R Medicine
Divisions: Faculty of Medicine
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 13 Aug 2020 08:18
Last Modified: 13 Aug 2020 08:18
URI: http://eprints.um.edu.my/id/eprint/25338

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