Heart rate variability and baroreflex sensitivity abnormalities in Guillain–Barré syndrome: a pilot study

Tan, Cheng Yin and Shahrizaila, Nortina and Yeoh, Kee Ying and Goh, Khean Jin and Tan, Maw Pin (2019) Heart rate variability and baroreflex sensitivity abnormalities in Guillain–Barré syndrome: a pilot study. Clinical Autonomic Research, 29 (3). pp. 339-348. ISSN 0959-9851, DOI https://doi.org/10.1007/s10286-018-0525-z.

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Official URL: https://doi.org/10.1007/s10286-018-0525-z


Objective: The current study aimed to investigate autonomic dysfunction in Guillain–Barré syndrome (GBS) patients and describe the results of computational heart rate variability (HRV)/baroreflex sensitivity (BRS) and autonomic challenge tests. Methods: GBS patients were consecutively recruited and the results were compared to age- and gender-matched healthy controls. A series of autonomic function tests including computation-dependent tests (power spectrum analysis of HRV and BRS at rest) and challenge maneuvers (deep breathing, eyeball compression, active standing, the Valsalva maneuver, sustained handgrip, and the cold pressor test) were performed. Results: Ten GBS patients (six men; mean age = 40.1 ± 13.9 years) and ten gender- and age-matched healthy controls were recruited. The mean GBS functional grading scale at disease plateau was 3.4 ± 1.0. No patients required intensive care unit admission or mechanical ventilation. Low-frequency HRV (p = 0.027), high-frequency HRV (p = 0.008), and the total power spectral density of HRV (p = 0.015) were significantly reduced in patients compared to controls. The mean up slope (p = 0.034), down slope (p = 0.011), and total slope (p = 0.024) BRS were significantly lower in GBS patients. The diastolic rise in blood pressure in the cold pressor test was significantly lower in GBS patients compared to controls (p = 0.008). Interpretation: Computation-dependent tests (HRV and BRS) were more useful for detecting autonomic dysfunction in GBS patients, whereas the cold pressor test was the only reliable challenge test, making it useful as a bedside measure of autonomic function in GBS patients. © 2018, Springer-Verlag GmbH Germany, part of Springer Nature.

Item Type: Article
Funders: University of Malaya (Project no. BK074-2017)
Uncontrolled Keywords: Autonomic dysfunction; Autonomic function test; Baroreflex sensitivity; Guillain–Barré syndrome; Heart rate variability
Subjects: R Medicine
Divisions: Faculty of Medicine
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 06 Jan 2020 02:35
Last Modified: 06 Jan 2020 02:35
URI: http://eprints.um.edu.my/id/eprint/23313

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