Central corneal thickness changes and horizontal corneal diameter in premature infants

Choo, May May and Yeong, Choo Mee and Grigg, John R. and Khaliddin, Nurliza and Kadir, Azida Juana and Barnes, Elizabeth Helen and Kamalden, Tengku Ain and Watson, Stephanie L. (2018) Central corneal thickness changes and horizontal corneal diameter in premature infants. Medicine, 97 (48). e13357. ISSN 0025-7974, DOI https://doi.org/10.1097/MD.0000000000013357.

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Official URL: https://doi.org/10.1097/MD.0000000000013357


To report observations of horizontal corneal diameter (HCD) and central corneal thickness (CCT) changes in premature infants with stable optic disc cupping and intraocular pressures (IOPs). The HCD and CCT at term serve as a baseline for premature infants. Sixty-three premature infants were enrolled in a prospective case series. HCD, CCT, and IOP were measured. RetCam images of the optic discs were used to evaluate the cup-disc ratio (CDR) and read by an independent masked observer. Data were collected at between preterm (32-36 weeks) and again at term (37-41 weeks) postconceptual age. Left eye measurements were used for statistical analysis. Left eye findings were combined to construct predictive models for HCD and CCT. The mean HCD was 9.1 mm (standard deviation [SD] = 0.7 mm) at preterm and 10.0 mm (SD = 0.52 mm) at term. The mean CCT preterm was 618.8 (SD = 72.9) mm and at term 563.9 (SD = 50.7) mm, respectively. The average preterm CDR was 0.31 and at maturity was 0.33. Average IOP of preterm and term was 13.1 and 14.11 mm Hg, respectively. There was significant linear correlation between HCD with the postmenstrual age (r = 0.40, P < .01) and the head circumference (r = 0.33, P < .05). Predictive models were constructed for HCD (R 2 = 0.52, 0.2 mm/wk) and CCT (R 2 = 0.23, 11.4 mm/wk) with postconceptual ages. The HCD and CCT variation did not affect IOP reading over time. CCT was not correlated with birth parameters and decreased as the infant reached term. Corneal diameter correlated with gestational age at birth and head circumference.

Item Type: Article
Funders: The study was partially funded by the following research grants: RG149-09HTM, THEQS-2009A, and HIR H-20001-00-E000056.
Uncontrolled Keywords: Corneal diameter; Intraocular pressure; Premature infants
Subjects: R Medicine
Divisions: Faculty of Medicine
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 27 May 2019 03:16
Last Modified: 27 May 2019 03:16
URI: http://eprints.um.edu.my/id/eprint/21312

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