The effect of obsessive compulsive symptoms on psychopathology in patients with schizophrenia

Ng, Boon Seng and Yee, Anne and Danaee, Mahmoud and Seng, Loh Huai and Jambunathan, Stephan Thevananthan (2018) The effect of obsessive compulsive symptoms on psychopathology in patients with schizophrenia. Archives of Clinical Psychiatry (Sao Paulo), 45 (3). pp. 61-66. ISSN 0101-6083, DOI

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Background: There is a growing interest on the impact of comorbid obsessive-compulsive symptoms (OCS) on the course and severity of schizophrenia in recent years. Objectives: This study determined the prevalence of OCS in schizophrenia patients and the clinical outcomes of the comorbidity. Methods: A total of 220 schizophrenia patients were recruited. All the participants completed Structure Clinical Interview version, Yale Brown Obsessive Compulsive Scale, Calgary Depression Scale for Schizophrenia, Columbia Suicide Severity Rating Scale and World Health Organization Quality of Life – Brief Version (WHOQOL-BREF). Results: Significantly higher number of schizophrenia patients with OCS were taking Clozapine (p = 0.023) and antidepressants (p = 0.013). Schizophrenia patients with OCS showed more severe positive (p < 0.001) and general symptoms (p < 0.001) of schizophrenia, higher depressive symptoms (p = 0.013), higher suicidality (p < 0.001), more hospitalization (p = 0.044), poorer physical (p = 0.034) and psychological (p = 0.032) domain in WHOQOLBREF. Discussion: Schizophrenia patients with OCS are associated with more severe psychopathology and depressive symptoms which subsequently suffered poorer physical and psychological health. Hence, recognition of OCS in schizophrenia and early initiation of effective treatment may be able to reduce the burden for people with chronic mental illness.

Item Type: Article
Funders: University of Malaya Research Management Centre: Postgraduate Research Fund (PO048-2014B)
Uncontrolled Keywords: Schizophrenia; obsessive compulsive symptoms; depression; quality of life
Subjects: R Medicine
Divisions: Faculty of Medicine
Deputy Vice Chancellor (Academic & International) Office > Academic Enhancement and Leadership Development Centre (Adec)
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 19 Mar 2019 02:50
Last Modified: 19 Mar 2019 02:51

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