A new thio-Schiff base fluorophore with copper ion sensing, DNA binding and nuclease activity

Vikneswaran, R. and Syafiq, M.S. and Eltayeb, N.E. and Kamaruddin, M.N. and Ramesh, Subramaniam and Yahya, Rosiyah (2015) A new thio-Schiff base fluorophore with copper ion sensing, DNA binding and nuclease activity. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 150. pp. 175-180. ISSN 1386-1425, DOI https://doi.org/10.1016/j.saa.2015.05.087.

Full text not available from this repository.
Official URL: http://dx.doi.org/10.1016/j.saa.2015.05.087


Copper ion recognition and DNA interaction of a newly synthesized fluorescent Schiff base (HPyETSC) were investigated using UV-vis and fluorescent spectroscopy. Examination using these two techniques revealed that the detection of copper by HPyETSC is highly sensitive and selective, with a detection limit of 0.39 μm and the mode of interaction between HPyETSC and DNA is electrostatic, with a binding constant of 8.97 × 104 M-1. Furthermore, gel electrophoresis studies showed that HPyETSC exhibited nuclease activity through oxidative pathway.

Item Type: Article
Funders: University Malaya: University of Malaya Research Grant (RP025A-14AFR), High Impact Research Grant (J-21002-73851) and Postgraduate Research Grant (PG105-2012B), University Malaya: Bright Sparks fellowship (BSP/APP/0944/2013)
Uncontrolled Keywords: Thiosemicarbazone; Fluorescent; Chemosensor; DNA binding; Chemical nucleases
Subjects: Q Science > Q Science (General)
Q Science > QC Physics
Q Science > QD Chemistry
Divisions: Faculty of Science > Department of Chemistry
Faculty of Science > Department of Physics
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 01 Oct 2018 03:19
Last Modified: 18 Mar 2019 08:30
URI: http://eprints.um.edu.my/id/eprint/19492

Actions (login required)

View Item View Item