Brexpiprazole for the treatment of schizophrenia

Yee, A. (2016) Brexpiprazole for the treatment of schizophrenia. Expert Review of Neurotherapeutics, 16 (2). pp. 109-122. ISSN 1473-7175, DOI

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Brexpiprazole (OPC-34712) is a novel serotonin-dopamine activity modulator, which has recently been approved by the U.S Food and Drug Administration for the treatment of schizophrenia. The aim of this paper is to systematically synthesize all data of the efficacy, safety and tolerability of Brexpiprazole in treating schizophrenia. The terms 'Brexpiprazole', 'OPC-34712' and 'schizophrenia' were searched. A total of 12 clinical trials with 7 available data records were found. The pooled effect size of Brexpiprazole 1 mg, 2 mg and 4 mg were all superior to placebo in terms of the change from baseline in positive and negative syndrome scale (PANSS) total score at week 6 (weighted mean difference = -3.74, p = 0.044; weighted mean difference = -5.76, p < 0.01 and weighted mean difference = -7.03, p < 0.01, respectively) when compared to that of the placebo in treating acute schizophrenia. Brexpiprazole displays a good safety and tolerability profile. The incidence of akathisia, headache, insomnia, sedation, agitation, diarrhea, weight gained, nausea, and dyspepsia are comparable to placebo.

Item Type: Article
Uncontrolled Keywords: Brexpiprazole; D2 receptor partial agonist; OPC-34712; Partial dopamine agonist; Schizophrenia
Subjects: R Medicine
Divisions: Faculty of Medicine
Depositing User: Ms. Juhaida Abd Rahim
Date Deposited: 31 May 2018 05:13
Last Modified: 31 May 2018 05:13

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