Diagnosis and management of Alzheimer's disease--an update

Srinivas, P. (1999) Diagnosis and management of Alzheimer's disease--an update. Medical Journal of Malaysia, 54 (4). pp. 541-550. ISSN 0300-5283, DOI 11072482.

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Official URL: http://www.ncbi.nlm.nih.gov/pubmed/11072482


Alzheimer's disease (AD) has become recognised as a major cause of morbidity and mortality in the ageing population worldwide. Over 20 million people worldwide are affected by AD, which ensures that the disease imposes a major economic burden. Alzheimer's disease is a progressive neurodegenerative disorder with characteristic clinical and neuropathological features. Neurofibrillary tangles, neuritic plaques and amyloid angiopathy occur in varying severity in brains of patient's with Alzheimer's disease. Biological markers of AD allowing an early definitive premorbid diagnoses are currently not available. Memory loss for recent events is invariable and often the earliest prominent symptom. Language disorders, difficulties with complex tasks, depression, psychotic symptoms and behavioral changes are other common manifestations of AD. Diagnosis involves the early detection of cognitive decline and ruling out other causes of dementia like vascular dementia, Lewy body dementia, fronto-temporal degeneration or reversible causes like hypothyroidism. Acetylcholinesterase inhibitors have shown to be effective in mild to moderate AD in improving the cognitive function of patients in clinical trials. Caregiver intervention programs have considerable potential to improve both the caregiver and patient quality of life.

Item Type: Article
Additional Information: Department of Medicine, University of Malaya, Kuala Lumpur
Uncontrolled Keywords: Alzheimer Disease/therapy; Caregivers; Cholinesterase Inhibitors/therapeutic use
Subjects: R Medicine
Divisions: Faculty of Medicine
Depositing User: Mr. Faizal Hamzah
Date Deposited: 10 Jun 2011 02:24
Last Modified: 01 Mar 2019 06:13
URI: http://eprints.um.edu.my/id/eprint/1544

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