Novel use of 3T MRI in assessment of optic nerve volume in glaucoma

Ramli, N.M. and Sidek, S. and Rahman, F.A. and Peyman, M. and Zahari, M. and Rahmat, K. and Ramli, N. (2014) Novel use of 3T MRI in assessment of optic nerve volume in glaucoma. Graefes Archive for Clinical and Experimental Ophthalmology, 252 (6). pp. 995-1000. ISSN 0721-832X,

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Purpose To measure optic nerve (ON) volume using 3 T magnetic resonance imaging (MRI), to correlate ON volume with retinal nerve fiber layer (RNFL) thickness, and to determine the viability of MRI as an objective tool in distinguishing glaucoma severity. Methods In this cross-sectional study, 30 severe glaucoma patients, 30 mild glaucoma patients and 30 age-matched controls were recruited. All subjects underwent standard automated perimetry, RNFL analysis and 3 T MRI examinations. Glaucoma patients were classified according to the Hodapp-Anderson-Parish classification. Pearson's correlation coefficient was used to correlate ON volume with RNFL, and receiver operating curve (ROC) analysis was performed to determine the sensitivity and specificity of ON volume in detecting glaucoma severity. Results Optic nerve volume was significantly lower in both the left and right eyes of the severe glaucoma group (168.70 +/- 46.28 mm(3); 167.40 +/- 45.36 mm(3)) than in the mild glaucoma group (264.03 +/- 78.53 mm(3); 264.76 +/- 78.88 mm(3)) and the control group (297.80 +/- 71.45 mm(3); 296.56 +/- 71.02 mm(3)). Moderate correlation was observed between: RNFL thickness and ON volume (r=0.51, p <0.001), and in mean deviation of visual field and optic nerve volume (r=0.60, p<0.001). ON volume below 236 mm(3) was 96 sensitive and 80 specific for the detection of severe glaucoma. Conclusions MRI measured optic nerve volume is a reliable method of assessing glaucomatous damage beyond the optic nerve head. A value of 236 mm(3) and below can be used to define severe glaucoma.

Item Type: Article
Additional Information: ISI Document Delivery No.: AK5UN Times Cited: 0 Cited Reference Count: 30 Ramli, Norlina M. Sidek, Sabrilhakim Rahman, Fadzlina A. Peyman, Mohammadreza Zahari, Mimiwati Rahmat, Kartini Ramli, Norlisah University of Malaya J-20518-73808, P0083/2012A This work was supported in part by funding from the University of Malaya research grants J-20518-73808 and P0083/2012A. Springer New york
Uncontrolled Keywords: Glaucoma MRI Optic nerve volume Retinal nerve fiber layer thickness open-angle glaucoma heidelberg retina tomograph scanning laser polarimeter lateral geniculate-nucleus coherence tomography visual pathway fiber layer gdx-vcc brain morphometry
Subjects: R Medicine
Divisions: Faculty of Medicine
Depositing User: Ms azrahani halim
Date Deposited: 11 Nov 2014 06:46
Last Modified: 11 Dec 2014 04:54

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