Cytotoxic triterpenoids from the bark of Aglaia smithii (Meliaceae)

Awang, Khalijah and Harneti, D. and Tjokronegoro, R. and Safari, A. and Supratman, U. and Loong, X.M. and Mukhtar, M.R. and Mohamad, K. and Hayashi, H. (2012) Cytotoxic triterpenoids from the bark of Aglaia smithii (Meliaceae). Phytochemistry Letters, 5 (3). pp. 496-499. ISSN 1874-3900,

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Two new dammarane triterpenoids, aglinone (1) and aglinin E (20S,24S-epoxy-25-hydroxy-1-en-dammarene) (2) along with three known compounds, 3-epiocotillol (3), aglinin A (4), and eichlerianic acid (5), were isolated from the bark of Aglaia smithii. The chemical structures of the new compound were elucidated on the basis of spectroscopic data interpretation. All the compounds isolated were evaluated for their cytotoxic effects against P-388 murine leukemia cells. Compounds 1, 2, 4 and 5 showed cytotoxicity against P-388 murine leukemia cells with IC50 values of 21, 42, 34, and 11 μg/mL, respectively.

Item Type: Article
Additional Information: Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur 59100, Malaysia-- DOI: 10.1016/j.phytol.2012.04.013
Uncontrolled Keywords: Aglinone; Aglinin E; Dammarane triterpenoid; Aglaia smithii; Cytotoxic activity.
Subjects: Q Science > QD Chemistry
Divisions: Faculty of Science > Department of Chemistry
Depositing User: Ms. Suhaila Syakila Alby
Date Deposited: 11 Nov 2014 04:20
Last Modified: 08 Mar 2019 08:36

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