Macroline, akuammiline, sarpagine, and ajmaline alkaloids from Alstonia macrophylla

Kam, Toh Seok and Lim, S.H. and Low, Y.Y. and Sinniah, S.K. and Yong, K.T. and Sim, K.S. (2013) Macroline, akuammiline, sarpagine, and ajmaline alkaloids from Alstonia macrophylla. Phytochemistry, 98. pp. 204-215. ISSN 0031-9422,

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A total of seventeen alkaloids, comprising six macroline (including alstofolinine A, a macroline indole incorporating a butyrolactone ring-E), two ajmaline, one sarpagine, and eight akuammiline alkaloids, were isolated from the stem-bark and leaf extracts of the Malayan Alstonia macrophylla. The structure and relative configurations of these alkaloids were established using NMR, MS and in several instances, confirmed by X-ray diffraction analysis. Six of these alkaloids were effective in reversing multidrug-resistance(MDR) in vincristine-resistant KB cells.

Item Type: Article
Additional Information: Department of Chemistry, University of Malaya
Uncontrolled Keywords: Alstonia macrophylla; Apocynaceae; Indole alkaloids; NMR X-ray crystallography;Reversal of multidrug-resistance
Subjects: Q Science > QD Chemistry
Divisions: Faculty of Science > Department of Chemistry
Depositing User: Ms. Suhaila Syakila Alby
Date Deposited: 15 Oct 2014 02:21
Last Modified: 22 Mar 2021 03:37

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