Kingianic acids A–G, endiandric acid analogues from endiandra kingiana.

Leong, K.H. (2014) Kingianic acids A–G, endiandric acid analogues from endiandra kingiana. Molecules Online, 19 (2). pp. 1732-1747. DOI

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A phytochemical investigation of the methanolic extract of the bark of Endiandra kingiana led to the isolation of seven new tetracyclic endiandric acid analogues, kingianic acids A–G (1–7), together with endiandric acid M (8), tsangibeilin B (9) and endiandric acid (10). Their structures were determined by 1D- and 2D-NMR analysis in combination with HRMS experiments. The structure of compounds 9 and 10 were confirmed by single-crystal X-ray diffraction analysis. These compounds were screened for Bcl-xL and Mcl-1 binding affinities and cytotoxic activity on various cancer cell lines. Compound 5 showed moderate cytotoxic activity against human colorectal adeno-carcinoma (HT-29) and lung adenocarcinoma epithelial (A549) cell lines, with IC50 values in the range 15–17 µM, and compounds 3, 6 and 9 exhibited weak binding affinity for the anti-apoptotic protein Mcl-1.

Item Type: Article
Funders: University of Malaya (PV050/2012A, RP001-2012B and RP001A-13BIO), Agence National de la Recherche (ANR), contract number ANR-2010-JCJC-702-1 and ICSN, CNRS for financial support
Uncontrolled Keywords: Endiandra kingiana; lauraceae; endiandric acids; kingianic acids; anti-apoptotic proteins; Bcl-xL; Mcl-1
Subjects: Q Science > Q Science (General)
Q Science > QD Chemistry
Q Science > QH Natural history > QH301 Biology
Q Science > QK Botany
R Medicine
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
R Medicine > RM Therapeutics. Pharmacology
R Medicine > RS Pharmacy and materia medica
R Medicine > RV Botanic, Thomsonian, and eclectic medicine
Divisions: Faculty of Medicine
Depositing User: Dr. Leong Kok Hoong
Date Deposited: 22 May 2014 02:21
Last Modified: 31 Jul 2018 04:23

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