Triterpenes and steroids from the leaves of Aglaia exima (Meliaceae)

Leong, K.H. (2012) Triterpenes and steroids from the leaves of Aglaia exima (Meliaceae). Fitoterapia, 83 (8). pp. 1391-1395. DOI

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A study on the leaves of Aglaia exima led to the isolation of one new and seven known compounds: six triterpenoids and two steroids. Their structures were elucidated and analyzed mainly by using spectroscopic methods; 1D and 2D NMR, mass spectrometry, UV spectrometry and X-ray. All the triterpenoids and steroids were measured in vitro for their cytotoxic activities against eight cancer cell lines; lung (A549), prostate (DU-145), skin (SK-MEL-5), pancreatic (BxPC-3), liver (Hep G2), colon (HT-29), breast (MCF-7) and (MDA-MB-231). The new cycloartane triterpenoid, 24(E)-cycloart-24-ene-26-ol-3-one 1, showed potent cytotoxic activity against colon (HT-29) cancer cell line (IC50 11.5 μM).

Item Type: Article
Funders: Institute of Research Management and Monitoring (IPPP) (PS344/2009C), Fundamental Research Grant Scheme (FRGS) (FP006/2011A), Research University Grant (RP001/2012A)
Uncontrolled Keywords: Aglaia exima; Meliaceae; Cycloartane; Cytotoxicity; Steroids; 24(E)-cycloart-24-ene-26-ol-3-one
Subjects: Q Science > Q Science (General)
Q Science > QD Chemistry
Q Science > QH Natural history > QH301 Biology
Q Science > QK Botany
R Medicine
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
R Medicine > RM Therapeutics. Pharmacology
R Medicine > RS Pharmacy and materia medica
R Medicine > RV Botanic, Thomsonian, and eclectic medicine
Divisions: Faculty of Medicine
Depositing User: Dr. Leong Kok Hoong
Date Deposited: 22 May 2014 02:18
Last Modified: 31 Jul 2018 04:26

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