Yahya, Tuan Syaripah Atiqah Najwa Tuan and Azmi, Norhaida Che and Yee, Fung Shin and Chyang, Pang Jyh and Ting, Ng Szu and Seng, Tan Chon (2024) The Effects of Tiger Milk Mushroom Lignosus rhinocerus TM02® (Agaricomycetes) on Leukemogenicity Tyrosine Kinase Cell Lines. International Journal of Medicinal Mushrooms, 26 (3). pp. 55-66. ISSN 1521-9437,
Full text not available from this repository.Abstract
Leukemia can be a result of genetic changes associated with protein tyrosine kinase activity such as in MPL W515L and BCR/ABL genes. However, the current conventional treatment of leukemia produces severe side effects that urge the approach to use natural products. A medicinal mushroom, Lignosus rhinocerus shows potential as an anti-cancer treatment. To investigate the effi cacy and mechanism of action of the L. rhinocerus cultivar (TM02 (R)) extract on leukemogenic tyrosine kinase cell lines, a cold-water extract (CWE) was produced by using TM02 (R) sclerotia powder at 4 degrees C. The carbohydrate and protein contents were found to be 77.24% and 1.75% respectively. In comparison to the normal Ba/F3 cell, the CWE TM02 (R) shows significant effects on exhibiting proliferation of Ba/F3 expressed MPL W515L and BCR/ABL, possibly due to the presence of phenolic compounds and antioxidant properties of TM02 (R), which contribute to act on various signaling pathways, and the reported apoptotic activity of CWE TM02 (R). In contrast, CWE TM02 (R) significantly exhibited high scavenging activity of both Ba/F3 expressed MPL W515L and BCR/ABL. At concentrations of 125 mu g/mL and 500 mu g/mL of CWE TM02 (R) decreased 49.5% and 67.5% of cell migration activity of Ba/F3 expressed MPL W515L and BCR/ABL respectively. Therefore, we postulate that CWE TM02 (R) has the capability to mediate the migration route of the leukemogenic tyrosine kinase cell lines.
| Item Type: | Article |
|---|---|
| Funders: | Ministry of Higher Education & Scientific Research (MHESR) (FRGS/1/2019/STG03/UNIKL/02/1) |
| Uncontrolled Keywords: | Lignosus rhinocerus; medicinal mushrooms; leukemia; leukemogenic tyrosine kinase |
| Subjects: | R Medicine > R Medicine (General) R Medicine > RM Therapeutics. Pharmacology R Medicine > RS Pharmacy and materia medica |
| Divisions: | Faculty of Medicine > Department of Molecular Medicine |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 14 Nov 2024 04:04 |
| Last Modified: | 14 Nov 2024 04:04 |
| URI: | http://eprints.um.edu.my/id/eprint/45907 |
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