Goh, Xiang Ting and Fong, Suh Kuan and Chai, Hwa Chia and Kee, Boon Pin and Chua, Kek Heng (2022) The first association study of Protein Tyrosine Phosphatase, Non-Receptor Type 2 (PTPN2) gene polymorphisms in Malaysian patients with Crohn's disease. Gene, 836. ISSN 0378-1119, DOI https://doi.org/10.1016/j.gene.2022.146661.
Full text not available from this repository.Abstract
Crohn's disease (CD) is one of the sub-entities of Inflammatory Bowel Disease which causes chronic inflammation in the gastrointestinal tract. The development of CD has shown to have a strong genetic association. Therefore, the present study aimed to investigate the association between genetic polymorphisms in a susceptible locus of CD, the protein tyrosine phosphatase, non-receptor type 2 (PTPN2) gene and the development of CD in Malaysian patients. A total of 137 CD patients and 274 matched healthy controls were recruited in the present study. Genomic DNA was extracted from the venous blood of participants and five targeted single nucleotide polymorphisms (SNPs) in the PTPN2 gene were genotyped using polymerase chain reaction. Associations between the SNPs and CD were determined using Fisher's exact test and odds ratio. Findings showed that all five selected SNPs were not significantly associated with the development of CD in Malaysian patients, which was in contrast to studies among the European populations. Malaysian Chinese with rs487273 heterozygous G/T genotype was found to have a lower occurrence of CD (P-value = 0.0253; OR = 0.4396). Patients with rs2542152 homozygous T genotype were associated with stricturing behaviour (P-value = 0.0302, OR = 2.9944). The rs16939895 A/G genotype was associated with inflammation at the ileum site (P-value = 0.0387, OR = 2.2105) while homozygous G genotype was associated with colonic CD (P-value = 0.0164, OR = 2.3917). Functional studies of these SNPs are needed to evaluate their potential use as a biomarker for disease phenotypes among Asian patients.
| Item Type: | Article |
|---|---|
| Funders: | University of Malaya Frontier Research Fund 2017 (Grant No: FG014/17AFR), Ministry of Higher Education Malaysia UK-MY Joint Partnership on Non-communicable Diseases (Newton-Medical Research Council 2019) (Grant No: IF077-2019) |
| Uncontrolled Keywords: | Crohns disease; Inflammatory bowel disease; PTPN2; SNPs |
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | Faculty of Medicine > Biomedical Science Department |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 20 Oct 2023 02:20 |
| Last Modified: | 20 Oct 2023 02:20 |
| URI: | http://eprints.um.edu.my/id/eprint/41852 |
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