MtDNA control region sequence polymorphisms and phylogenetic analysis of Malay population living in or around Kuala Lumpur in Malaysia

Maruyama, S. and Nohira-Koike, C. and Minaguchi, K. and Nambiar, P. (2010) MtDNA control region sequence polymorphisms and phylogenetic analysis of Malay population living in or around Kuala Lumpur in Malaysia. International Journal of Legal Medicine, 124 (2). pp. 165-170. ISSN 0937-9827, DOI https://doi.org/10.1007/s00414-009-0355-6.

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Abstract

Control region polymorphisms in the mitochondrial DNA of 124 unrelated individuals from the Malay population living in or around Kuala Lumpur in Malaysia were investigated and phylogenetic haplogroup lineages were determined. The intergenic COII/tRNALys 9-bp deletion, 3010 and 5178 mutations, and several coding region polymorphisms were examined to discriminate some phylogenetic haplogroups. Sequence comparison of the control regions led to the identification of 117 mitochondrial haplotypes, in which 103 types were observed in only one individual and the other nine types were shared by more than two individuals. Gene diversity was estimated to be 0.997. Phylogenetic haplogroup determination revealed that the gene pool of the modern Malay population in Malaysia consisted mainly of southeast Asian, east Asian, unidentified and unique, and aboriginal southeast-specific haplogroups. These results suggest a multi-original nature for the modern Malay population. The present database may help not only in personal identification but also in determining geographic origin in forensic casework in Malaysian, Southeast Asian and East Asian populations.

Item Type:	Article
Funders:	UNSPECIFIED
Additional Information:	ISI Document Delivery No.: 555OM Times Cited: 5 Cited Reference Count: 46 Maruyama, S. Nohira-Koike, C. Minaguchi, K. Nambiar, P. Ministry of Education, Science, Sports and Culture; 14370701; 29791646 We would like to thank Associate Professor Jeremy Williams, Laboratory of International Dental Information, Tokyo Dental College, for editing this manuscript. This research was partially supported by the Ministry of Education, Science, Sports and Culture; Grant-in-Aid for Scientific Research (B) (14370701); and Grant-in-Aid for Young Scientists Research (B) (29791646). Springer New york
Uncontrolled Keywords:	Mitochondrial DNA Polymorphism Control region Haplogroup Malay population dna control region mitochondrial genome variation japanese individuals ethnic populations korean population southeast asians han population lineages india differentiation
Subjects:	R Medicine > RK Dentistry
Divisions:	Faculty of Dentistry > Dept of General Dental Practice And Oral & Maxillofacial Imaging
Depositing User:	Mr Ahmad Azwan Azman
Date Deposited:	02 Nov 2012 01:30
Last Modified:	02 Nov 2012 01:30
URI:	http://eprints.um.edu.my/id/eprint/3863

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