Azhari, Nurul Raihana Binti and Hui, Boon Yih and Zain, Nur Nadhirah Mohamad and Suah, Fail Bukhari Mohd and Mohamad, Sharifah and Yahaya, Noorfatimah and Raoov, Muggundha (2020) Enantiomeric Separation of Azole Antifungal Compounds using Chromatographic and Electrophoretic Techniques: A Mini Review. Sains Malaysiana, 49 (11). pp. 2699-2714. ISSN 0126-6039, DOI https://doi.org/10.17576/jsm-2020-4911-09.
Full text not available from this repository.Abstract
The separation of azole antifungal chiral compounds has gaining much interests since 1980's as they possess different biological, pharmaceutical, and pharmacokinetic behaviors at various toxicity levels. Numerous studies have looked into this subject matter, and therefore, this review presents an overview on different chiral separation techniques that have been developed such as liquid chromatography (LC), gas chromatography (GC), supercritical fluid chromatography (SFC), and capillary electrophoresis (CE). This comprehensive review also discusses the mechanisms of the developed analytical methods such as preparation techniques and optimization parameters towards the enantioseparation performances as well as their advantages and drawbacks. Lastly, the conclusion and future directions of the chiral separation, particularly for azole compounds are provided accordingly.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | Antifungal compounds; azole; capillary electrophoresis; chiral separation; chromatographic analysis |
| Subjects: | Q Science > Q Science (General) Q Science > QD Chemistry |
| Divisions: | Faculty of Science Faculty of Science > Department of Chemistry |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 29 Nov 2023 13:07 |
| Last Modified: | 29 Nov 2023 13:07 |
| URI: | http://eprints.um.edu.my/id/eprint/36275 |
Actions (login required)
 |
View Item |
