Venkatraman, Senthil Kumar and Choudhary, Rajan and Krishnamurithy, Genasan and Raghavendran, Hanumantha Rao Balaji and Murali, Malliga Raman and Kamarul Zaman, Tunku and Suresh, Anushree and Abraham, Jayanthi and Swamiappan, Sasikumar (2021) Biomineralization, mechanical, antibacterial and biological investigation of larnite and rankinite bioceramics. Materials Science & Engineering C-Materials for Biological Applications, 118. ISSN 0928-4931, DOI https://doi.org/10.1016/j.msec.2020.111466.
Full text not available from this repository.Abstract
This work is aimed to develop a biocompatible, bactericidal and mechanically stable biomaterial to overcome the challenges associated with calcium phosphate bioceramics. The influence of chemical composition on synthesis temperature, bioactivity, antibacterial activity and mechanical stability of least explored calcium silicate bioceramics was studied. The current study also investigates the biomedical applications of rankinite (Ca3Si2O7) for the first time. Sol-gel combustion method was employed for their preparation using citric acid as a fuel. Differential thermal analysis indicated that the crystallization of larnite and rankinite occurred at 795 degrees C and 1000 degrees C respectively. The transformation of secondary phases into the desired product was confirmed by XRD and FT-IR. TEM micrographs showed the particle size of larnite in the range of 100-200 nm. The surface of the samples was entirely covered by the dominant apatite phase within one week of immersion. Moreover, the compressive strength of larnite and rankinite was found to be 143 MPa and 233 MPa even after 28 days of soaking in SBF. Both samples prevented the growth of clinical pathogens at a concentration of 2 mg/mL. Larnite and rankinite supported the adhesion, proliferation and osteogenic differentiation of hBMSCs. The variation in chemical composition was found to influence the properties of larnite and rankinite. The results observed in this work signify that these materials not only exhibit faster biomineralization ability, excellent cytocompatibility but also enhanced mechanical stability and antibacterial properties.
| Item Type: | Article |
|---|---|
| Funders: | Vellore Institute of Technology (VIT), Ministry of Science and Higher Education of the Russian Federation[K4-2019-018], Ministry of Science and Higher Education of the Russian Federation[211], Malaysia Ministry of Higher Education, Transdisciplinary Research Grant Scheme[TR001A-2016A], Malaysia Ministry of Higher Education, Transdisciplinary Research Grant Scheme[TRGS/1/2016/UM/01/4/1] |
| Uncontrolled Keywords: | Silicates;Apatite;Dissolution;Resorbability;Compressive strength;Osteogenic differentiation |
| Subjects: | R Medicine |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 16 Jun 2022 02:04 |
| Last Modified: | 16 Jun 2022 02:04 |
| URI: | http://eprints.um.edu.my/id/eprint/34292 |
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