Lau, Min Yi and Teng, Fui Enn and Chua, Kek Heng and Ponnampalavanar, Sasheela and Chong, Chun Wie and Jabar, Kartini Abdul and Teh, Cindy Shuan Ju (2021) Molecular characterization of carbapenem resistant Klebsiella pneumoniae in Malaysia hospital. Pathogens, 10 (3). ISSN 2076-0817, DOI https://doi.org/10.3390/pathogens10030279.
Full text not available from this repository.Abstract
The emergence of carbapenem-resistant Klebsiella pneumoniae (CRKP) is a great concern, as carbapenems are the last-line therapy for multidrug-resistant Gram-negative bacteria infections. This study aims to report the epidemiology of CRKP in a teaching hospital in Malaysia based on the molecular genotypic and clinical characteristics of the isolates. Sixty-three CRKP strains were isolated from a tertiary teaching hospital from January 2016 until August 2017. Carbapenemase genes were detected in 55 isolates, with bla(OXA-48) (63.5%) as the predominant carbapenemase gene, followed by bla(NDM) (36.5%). At least one porin loss was detected in nine isolates. Overall, 63 isolates were divided into 30 clusters at similarity of 80% with PFGE analysis. Statistical analysis showed that in-hospital mortality was significantly associated with the usage of central venous catheter, infection or colonization by CRKP, particularly NDM-producers. In comparison, survival analysis using Cox proportional hazards regression identified a higher hazard ratio for patients with a stoma and patients treated with imipenem but a lower hazard ratio for patients with NDM-producing CRKP. OXA-48 carbapenemase gene was the predominant carbapenemase gene in this study. As CRKP infection could lead to a high rate of in-hospital mortality, early detection of the isolates was important to reduce their dissemination.
| Item Type: | Article |
|---|---|
| Funders: | International Society for Infectious Diseases (ISID)[IF2016-2015] |
| Uncontrolled Keywords: | Carbapenem-resistant Klebsiella pneumoniae;Enterobacteriaceae;OXA-48;NDM;Carbapenemase;PFGE |
| Subjects: | R Medicine R Medicine > RC Internal medicine |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 22 Aug 2022 02:16 |
| Last Modified: | 22 Aug 2022 02:16 |
| URI: | http://eprints.um.edu.my/id/eprint/28736 |
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