Poh, Mau Ern and Liam, Chong Kin and Mun, Kein Seong and Chai, Chee Shee and Wong, Chee Kuan and Tan, Jiunn Liang and Loh, Thian Chee and Chin, Ka Kiat (2019) Epithelial‐to‐mesenchymal transition (EMT) to sarcoma in recurrent lung adenosquamous carcinoma following adjuvant chemotherapy. Thoracic Cancer, 10 (9). pp. 1841-1845. ISSN 1759-7706, DOI https://doi.org/10.1111/1759-7714.13156.
Full text not available from this repository.Abstract
Adjuvant chemotherapy has long been indicated to extend survival in completely resected stage IB to IIIA non-small cell lung cancer (NSCLC). However, there is accumulating evidence that chemotherapy or chemoradiotherapy can induce epithelial-to-mesenchymal transition (EMT) in disseminated or circulating NSCLC cells. Here, we describe the first case of EMT as the cause of recurrence and metastasis in a patient with resected stage IIB lung adenosquamous carcinoma after adjuvant chemotherapy. We review the literature and explore the possible mechanisms by which EMT occurs in disseminated tumor cells (DTC) or circulating tumor cells (CTC) in response to adjuvant chemotherapy (cisplatin) as a stressor. We also explore the possible therapeutic strategies to reverse EMT in patients with recurrence. In summary, although adjuvant cisplatin-based chemotherapy in resected NSCLC does extend survival, it may lead to the adverse phenomenon of EMT in disseminated tumor cells (DTC) or circulating tumor cells (CTC) causing recurrence and metastasis. © 2019 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | Adenosquamous lung carcinoma; adjuvant chemotherapy; epithelial-to-mesenchymal transition; lung cancer; sarcoma |
| Subjects: | R Medicine |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 12 Feb 2020 01:20 |
| Last Modified: | 23 Mar 2021 02:26 |
| URI: | http://eprints.um.edu.my/id/eprint/23749 |
Actions (login required)
 |
View Item |
