Hepatoprotective effects of Orthosiphon stamineus extract on thioacetamide-induced liver cirrhosis in rats

Alshawsh, M.A. and Abdulla, M.A. and Ismail, S. and Amin, Z.A. (2011) Hepatoprotective effects of Orthosiphon stamineus extract on thioacetamide-induced liver cirrhosis in rats. Evidence-Based Complementary and Alternative Medicine, 2011. pp. 1-6. ISSN 1741-427X

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Abstract

Orthosiphon stamineus as medicinal plant is commonly used in Malaysia for treatment of hepatitis and jaundice; in this study, the ethanol extracts were applied to evaluate the hepatoprotective effects in a thioacetamide-induced hepatotoxic model in Sprague Dawley rats. Five groups of adult rats were arranged as follows:Group 1 (normal control group), Group 2 Thioacetamide (TAA) as positive control (hepatotoxic group), Group 3 Silymarin as a well-known standard drug (hepatoprotective group), and Groups 4 and 5 as high and low dose (treatment groups). After 60-day treatment, all rats were sacrificed. The hepatotoxic group showed a coarse granulation on the liver surface when compared to the smooth aspect observed on the liver surface of the other groups. Histopathological study confirmed the result; moreover, there was a significant increase in serum liver biochemical parameters (ALT, AST, ALP, and Bilirubin) and the level of liver Malondialdehyde (MDA), accompanied by a significant decrease in the level of total protein and Albumin in the TAA control group when compared with that of the normal group. The high-dose treatment group (200mg/kg) significantly restored the elevated liver function enzymes near to normal. This study revealed that 200 mg/kg extracts of O. stamineus exerted a hepatoprotective effect.

Item Type: Article
Uncontrolled Keywords: Anti-hepatotoxic, Thioacetamide-induced hepatotoxicity, Antioxidant, Hepatoprotective activity, In vivo experimental animal model, Free radicals, Oxidative stress, Immunohistopathology, Drug safety
Subjects: R Medicine
Divisions: Faculty of Medicine
Depositing User: Assoc.Prof. Mohammed Abdullah Mahdi Alshawsh
Date Deposited: 12 Nov 2014 04:11
Last Modified: 12 Nov 2014 04:11
URI: http://eprints.um.edu.my/id/eprint/9963

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