Gopinath, S.C.B. and Tang, T.H. and Citartan, M. and Chen, Y. and Lakshmipriya, T. (2014) Current aspects in immunosensors. Biosensors and Bioelectronics, 57. p. 292. ISSN 0956-5663, DOI https://doi.org/10.1016/j.bios.2014.02.029.
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Abstract
Sensing applications can be used to report biomolecular interactions in order to elucidate the functions of molecules. The use of an analyte and a ligand is a common set-up in sensor development. For several decades, antibodies have been considered to be potential analytes or ligands for development of socalled "immunosensors." In an immunosensor, formation of the complex between antibody and antigen transduces the signal, which is measurable in various ways (e.g., both labeled and label-free based detection). Success of an immunosensor depends on various factors, including surface functionalization, antibody orientation, density of the antibody on the sensor platform, and configuration of the immunosensor. Careful optimization of these factors can generate clear-cut results for any immunosensor. Herein, current aspects, involved in the generated immunosensors, are discussed.
| Item Type: | Article |
|---|---|
| Funders: | USM RU Grant 1001/CIPPT/813043, UM-MoHE HIRH-18001-C00020, UM-MoHE HIRH-18001-C00009, Mosti (02-01-03-SF0699) |
| Uncontrolled Keywords: | Immunoglobulin; Immunosensor; Antibody; Antigen |
| Subjects: | R Medicine > RK Dentistry |
| Divisions: | Faculty of Dentistry |
| Depositing User: | Mr Ahmad Azwan Azman |
| Date Deposited: | 12 Nov 2014 03:34 |
| Last Modified: | 12 Nov 2014 03:34 |
| URI: | http://eprints.um.edu.my/id/eprint/9954 |
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