Comparison of serum F2 isoprostane levels in diabetic patients and diabetic patients infected with Burkholderia pseudomallei.

Puthucheary, S.D.; Nathan, S.A. (2008) Comparison of serum F2 isoprostane levels in diabetic patients and diabetic patients infected with Burkholderia pseudomallei. Singapore medical journal, 49 (2). pp. 117-20. ISSN 0037-5675

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Abstract

The oxidative stress theory proposes that severe sepsis leads to activation of neutrophils and macrophages which subsequently release reactive oxygen-free radicals that may result in lipid peroxidation of endothelial and epithelial cell membrane phospholipids. This chain reaction results in increased levels of isoprostanes, which are thought to contribute to much of the end-stage tissue damage seen in serious infections, such as melioidosis. We believe that this is the first report linking in vivo oxidative stress status and diabetic patients infected with B. pseudomallei.

Item Type: Article
Journal or Publication Title: Singapore medical journal
Additional Information: Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia
Uncontrolled Keywords: Burkholderia pseudomallei; Case-Control Studies
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Medicine
Depositing User: Mr. Faizal Hamzah
Date Deposited: 23 Apr 2011 11:04
Last Modified: 23 Apr 2011 11:04
URI: http://eprints.um.edu.my/id/eprint/979

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