The association of Streptococcus bovis/gallolyticus with colorectal tumors: The nature and the underlying mechanisms of its etiological role.

Abdulamir, A.S.; Hafidh, R.R.; Bakar, F.A. (2011) The association of Streptococcus bovis/gallolyticus with colorectal tumors: The nature and the underlying mechanisms of its etiological role. Journal of Experimental & Clinical Cancer Research, 30. p. 11. ISSN 1756-9966

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Abstract

ABSTRACT: Streptococcus bovis (S. bovis) bacteria are associated with colorectal cancer and adenoma. S. bovis is currently named S. gallolyticus. 25 to 80% of patients with S. bovis/gallolyticus bacteremia have concomitant colorectal tumors. Colonic neoplasia may arise years after the presentation of bacteremia or infectious endocarditis of S. bovis/gallolyticus. The presence of S. bovis/gallolyticus bacteremia and/or endocarditis is also related to the presence of villous or tubular-villous adenomas in the large intestine. In addition, serological relationship of S. gallolyticus with colorectal tumors and direct colonization of S. gallolyticus in tissues of colorectal tumors were found. However, this association is still under controversy and has long been underestimated. Moreover, the etiological versus non-etiological nature of this associationis not settled yet. Therefore, by covering the most of up to date studies, this review attempts to clarify the nature and the core of S. bovis/gallolyicus association with colorectal tumors and analyze the possible underlying mechanisms.

Item Type: Article
Journal or Publication Title: Journal of Experimental & Clinical Cancer Research
Uncontrolled Keywords: Colorectal cancer; Bacterial pathogens
Subjects: R Medicine > R Medicine (General)
Divisions: UNSPECIFIED
Depositing User: Mr. Faizal Hamzah
Date Deposited: 25 Feb 2011 11:41
Last Modified: 17 Jun 2011 09:20
URI: http://eprints.um.edu.my/id/eprint/86

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