BODIPY dyes in photodynamic therapy

Kamkaew, Anyanee and Lim, Siang Hui and Lee, Hong Boon and Kiew, Lik Voon and Chung, Lip Yong and Burgess, Kevin (2013) BODIPY dyes in photodynamic therapy. Chemical Society Reviews, 42 (1). pp. 77-88. ISSN 0306-0012, DOI https://doi.org/10.1039/c2cs35216h.

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Abstract

BODIPY dyes tend to be highly fluorescent, but their emissions can be attenuated by adding substituents with appropriate oxidation potentials. Substituents like these have electrons to feed into photoexcited BODIPYs, quenching their fluorescence, thereby generating relatively long-lived triplet states. Singlet oxygen is formed when these triplet states interact with O-3(2). In tissues, this causes cell damage in regions that are illuminated, and this is the basis of photodynamic therapy (PDT). The PDT agents that are currently approved for clinical use do not feature BODIPYs, but there are many reasons to believe that this situation will change. This review summarizes the attributes of BODIPY dyes for PDT, and in some related areas.

Item Type:	Article
Funders:	UNSPECIFIED
Uncontrolled Keywords:	singlet oxygen generation; tunable fluorescent dyes; in-vitro protoporphyrin-ix; up-conversion; photosensitizing properties; efficient photosensitizers; photophysical properties; 5-aminolevulinic acid; clinical-applications
Subjects:	R Medicine R Medicine > RS Pharmacy and materia medica
Divisions:	Faculty of Medicine
Depositing User:	Ms Haslinda Lahuddin
Date Deposited:	11 Nov 2013 03:22
Last Modified:	20 Nov 2019 01:35
URI:	http://eprints.um.edu.my/id/eprint/8524

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