Toxoplasmosis in HIV/AIDS patients: a current situation

Nissapatorn, V. and Lee, C. and Quek, K.F. and Leong, C.L. and Mahmud, R. and Abdullah, K.A. (2004) Toxoplasmosis in HIV/AIDS patients: a current situation. Japanese Journal of Infectious Diseases, 57 (4). pp. 160-165. ISSN 1344-6304

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Abstract

The seroprevalence of toxoplasmosis among 505 of human immunodeficiency virus (HIV)/AIDS patients was 226 (44.8; 95 CI 42.64-51.76): 27 (47.4) and 199 (44.4) showed Toxoplasma seropositivity with and without toxoplasmic encephalitis (TE), respectively (P<0.05). The majority of these patients were in the 25-34 age group (44 versus 39), male (86 versus 76), and Chinese (49 versus 53), though no statistical significance was found between the two. Significant differences between these two groups were noted, however, in terms of marital status, occupation, and present address. The heterosexual exhibited the most frequent behavior at risk for HIV infection, and accounted for 51 and 59 of patients with and without TE, respectively. Only 17/260 (6.5) and 1/137 (0.7) of them later acquired TE after receiving primary chemoprophylaxis (cotrimoxazole) and antiretroviral therapy including HAART (P<0.05). Fifty-seven (11.3) out of those 505 patients were diagnosed with AIDS-related TE. The most common clinical manifestation was headache (56). The computed tomography scan findings showed most lesions to be multiple (96.4), hypodense (66.7), and in the parietal region (39.3). Twenty-seven (47.4) patients had chronic (latent) Toxoplasma infection as evidenced by seropositivity for anti-Toxoplasma (IgG) antibody. At the time of diagnosis, the range of CD4 cell count was from 0-239 with a median of 25 cells/cumm. We also found that a CD4 count of less than 100 cells/cumm was significantly associated with development of TE (P<0.05). Clinical outcomes showed that among those who survived, 21 (36.8), 16 (28.1), and 2 (3.5) of patients had completed treatment, transferred out, and were lost to follow up, respectively. Unfortunately, 18 (31.6) of the cases were officially pronounced dead. Overall, 7 (12.3) patients were detected as recurrent TE in this study.

Item Type: Article
Additional Information: ISI Document Delivery No.: 851ER Times Cited: 30 Cited Reference Count: 38 Nissapatorn, V Lee, C Quek, KF Leong, CL Mahmud, R Abdullah, KA Natl inst infectious diseases Tokyo
Uncontrolled Keywords: Acquired-immunodeficiency-syndrome hiv-infected patients aids patients encephalitis prevalence virus risk prophylaxis therapy women
Subjects: R Medicine
Divisions: Faculty of Medicine
Depositing User: Ms azrahani halim
Date Deposited: 10 Oct 2013 01:45
Last Modified: 10 Oct 2013 01:45
URI: http://eprints.um.edu.my/id/eprint/8447

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