Protective effect of Carica papaya L leaf extract against alcohol induced acute gastric damage and blood oxidative stress in rats

Indran, M. and Mahmood, A.A. and Kuppusamy, U.R. (2008) Protective effect of Carica papaya L leaf extract against alcohol induced acute gastric damage and blood oxidative stress in rats. West Indian Medical Journal, 57 (4). pp. 323-326. ISSN 0043-3144

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Abstract

The effects of Carica papaya leaf (CPL) aqueous extract on alcohol induced acute gastric damage and the immediate blood oxidative stress level were studied in rats. The results showed that gastric ulcer index was significantly reduced in rats pretreated with CPL extract as compared with alcohol treated controls. The in vitro studies using 2,2-Diphenyl-l-Picryl-Hydrazyl (DPPH) assay showed strong antioxidant nature of CPL extract. Biochemical analysis indicated that the acute alcohol induced damage is reflected in the alterations of blood oxidative indices and CPL extract offered some protection with reduction in plasma lipid peroxidation level and increased erythrocyte glutathione peroxidase activity. Carica papaya leaf may potentially serve as a good therapeutic agent for protection against gastric ulcer and oxidative stress.

Item Type: Article
Additional Information: Indran, M. Mahmood, A. A. Kuppusamy, U. R.
Uncontrolled Keywords: Carica papaya leaf (CPL); 2,2-Diphenyl-l-Picryl-Hydrazyl (DPPH)
Subjects: R Medicine
Divisions: Faculty of Medicine
Depositing User: Ms Haslinda Lahuddin
Date Deposited: 29 Jul 2013 00:42
Last Modified: 29 Jul 2013 00:42
URI: http://eprints.um.edu.my/id/eprint/8226

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