Nutritional composition, antioxidant activities, and antiulcer potential of lentinus squarrosulus(Mont.) mycelia extract

Omar, N.A.M. and Abdullah, N. and Kuppusamy, U.R. and Abdulla, M.A. and Sabaratnam, V. (2011) Nutritional composition, antioxidant activities, and antiulcer potential of lentinus squarrosulus(Mont.) mycelia extract. Evidence-Based Complementary and Alternative Medicine. pp. 1-8. ISSN 1741-427X

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Abstract

Water extract of Lentinus squarrosulus mycelia was analysed for nutritional content, antioxidant capacity, and antiulcer ability. The extract contains high protein (57.6 g/100 g) and low total fat (0.5 g/100 g) and is rich in magnesium (0.4 g/100 g), potassium (3.8 g/100 g), vitamins B1 (1.42mg/100 g), and B3 (194.29 mg/100 g) with total phenolic content of 39.16 mg/100 g. The cupric reducing antioxidant capacity and 1,1-diphenyl-2-picrylhydrazyl radical scavenging activity of the extract were A(450) of 0.20 perpendicular to 0.03 at 0.5mg/ml and IC(50) of 14.29 mg/ml, respectively. Oral feeding of L. squarrosulus extract (250 mg/kg) offered significant gastric mucosal protection of Sprague-Dawley rats compared to cimetidine (50 mg/kg). The ulcer healing rate of ulcerated rats after 24, 48, and 72 hours of treatment was 82, 90, and 100, respectively. The IL-1 beta level in the serum and the NF-kappa B level in the tissues indicate that the healing potential was associated with attenuation of proinflammatory cytokines.

Item Type: Article
Additional Information: Omar, Nor Adila Mhd Abdullah, Noorlidah Kuppusamy, Umah Rani Abdulla, Mahmood Ameen Sabaratnam, Vikineswary
Uncontrolled Keywords: Lentinus squarrosulus mycelia
Subjects: R Medicine
Divisions: Faculty of Medicine
Depositing User: Ms Haslinda Lahuddin
Date Deposited: 23 Jul 2013 00:18
Last Modified: 23 Jul 2013 00:18
URI: http://eprints.um.edu.my/id/eprint/8176

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