Neuromodulatory effect of acrous calamus leaves extract on dopaminergic system in mice

VengadeshPrabu, K. and George, T. and VinothKumar, R. and Nancy, J. and Kalaivani, M. and Vijayapandi, P. (2009) Neuromodulatory effect of acrous calamus leaves extract on dopaminergic system in mice. International Journal of PharmTech Research, 1 (4). pp. 1255-1259. ISSN 0974-4304,

Preview

PDF Neuromodulatory_effect_of_Acrous_calamus_leaves_extract_on_dopaminergic_system_in_mice.pdf - Published Version Download (178kB)

Abstract

Acorus calamus (Family: Araceae), available in India and many parts of world, found to have various Pharmacological activities such as analgesic, anti-convulsant, anti-spasmodic, anti-inflammatory, anti-bacterial, anti ulcer and cyto-protective. In present study, we have investigated effects of methanol (ACME) and acetone (ACAE) extract of Acorus calamus leaves against APM induced stereotypy and haloperidol induced catalepsy. APM induced stereotypy behavior, which reached peak at 15 min period. ACME (20 and 50 mg/Kg oral) administration significantly reversed stereotypy induced by APM. But ACAE at doses used (5, 20 and 50 mg/Kg oral) could not alter the stereotypy induced by APM. Whereas ACME (50 mg/Kg) and ACAE (20, 50 mg/Kg) administration significantly potentiated the haloperidol induced catalepsy in mice.

Item Type:	Article
Funders:	UNSPECIFIED
Uncontrolled Keywords:	Acorus calamus; Catalepsy; stereotypy
Subjects:	R Medicine
Divisions:	Faculty of Medicine
Depositing User:	Ms azrahani halim
Date Deposited:	22 Jul 2013 02:29
Last Modified:	06 Jan 2015 04:09
URI:	http://eprints.um.edu.my/id/eprint/8140

Actions (login required)

View Item