Role of surface activity in the biological actions of ranitidine and famotidine

Pandi, P.V. and Kole, P.L. and Mishra, P.K.R. and Shanmukha, I. and Girish, K. and Nagappa, A.N. (2004) Role of surface activity in the biological actions of ranitidine and famotidine. Colloids and Surfaces B-Biointerfaces, 35 (3-4). pp. 243-248. ISSN 0927-7765,

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Abstract

The role of surface activity has been studied in the biological actions of ranitidine (RNT) and famotidine (FMT). The drugs have been shown to generate liquid membranes in series with a supporting membrane with the virtue of their amphiphilicity. Transport of histamine, acetylcholine, and ions (chloride, bicarbonate, potassium, sodium and calcium) have been studied in the presence of liquid membranes generated by surface-active RNT and FMT. The data on the modifications in the permeability of histamine, acetylcholine and ions indicate that the liquid membranes generated by RNT and FMT may play a significant role in their biological action. The surface-active nature of the drugs has been discussed with relevance to their pharmacological effects. (C) 2004 Elsevier B.V. All rights reserved.

Item Type:	Article
Funders:	UNSPECIFIED
Additional Information:	Pandi, PV Kole, PL Mishra, PKR Shanmukha, I Girish, K Nagappa, AN
Uncontrolled Keywords:	Surface activity; Ranitidine; Famotidine; Kesting�s hypothesis; Liquid membrane phenomenon
Subjects:	R Medicine
Divisions:	Faculty of Medicine
Depositing User:	Ms azrahani halim
Date Deposited:	17 Jul 2013 02:58
Last Modified:	20 Oct 2014 02:26
URI:	http://eprints.um.edu.my/id/eprint/8135

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