Microwave-assisted solvent-free synthesis of 3- (4-substituted piperazin-1-yl)alkyl imidazo 2,1-b 1,3 benzothiazol-2(3H)-ones as serotonin(3) (5-HT3) receptor antagonists

Mahesh, R. and Perumal, R.V. and Pandi, P.V. (2005) Microwave-assisted solvent-free synthesis of 3- (4-substituted piperazin-1-yl)alkyl imidazo 2,1-b 1,3 benzothiazol-2(3H)-ones as serotonin(3) (5-HT3) receptor antagonists. Pharmazie, 60 (6). pp. 411-414. ISSN 0031-7144

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Abstract

A series of novel 3-(4-substituted piperazin-1-yl)alkylimidazo2,1-b1,3benzothiazol-2(3H)-ones were prepared by microwave irradiation using alumina as solid support and also by a conventional method. The compounds were characterized by spectral data and the purity was ascertained by microanalysis. The synthesized compounds were evaluated for 5-hydroxytryptamine(3) antagonisms in a longitudinal muscle-myenteric plexus preparation from guinea pig ileum against the 5-hydroxytryptamine3 agonist, 2-methyl-5-hydroxytryptamine. Among the test compounds, 3-2-(4-methylpiperazin-1-yl)ethylimidazo2,1-b1,3benzothiazol-2(3H)-one (3b) showed most favorable 5-hydroxytryptamine3 antagonism (pA(2) 6.7) in the isolated guinea pig ileum.

Item Type: Article
Additional Information: Mahesh, R Perumal, RV Pandi, PV
Subjects: R Medicine
Divisions: Faculty of Medicine
Depositing User: Ms azrahani halim
Date Deposited: 17 Jul 2013 00:50
Last Modified: 17 Jul 2013 00:50
URI: http://eprints.um.edu.my/id/eprint/8134

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