Ariffin, Azhar and Khan, M.N. and Sim, Y.L. (2008) Kinetics and mechanism of large rate enhancement in an Acidic Aqueous Cleavage of the Tertiary Amide Bond of N-(2-Methoxyphenyl)-N'-Morpholinophthalamide (1). Bioorganic Chemistry, 36 (4-6). pp. 178-182. ISSN 0045-2068, DOI https://doi.org/10.1016/j.bioorg.2008.03.003.
Full text not available from this repository.Abstract
The rate of conversion of 1 to N-(2-methoxyphenyl)phthalimide (2) within [HCI] range 5.0 x 10(-3)-1.0 M at 1.0 M ionic strength (by NaCl) reveals the presence of both uncatalyzed and specific acid-catalyzed kinetic terms in the rate law. Intramolecular carboxamide group-assisted cleavage of amide bond of 1 reveals rate enhancement of much larger than 10(6)-fold compared to the expected rate of analogous intermolecular reaction. (C) 2008 Elsevier Inc. All rights reserved.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Additional Information: | Department of Chemistry, Faculty of Science Building, University of Malaya, 50603 Kuala Lumpur, MALAYSIA |
| Uncontrolled Keywords: | Acids/*chemistry; Hydrogen-Ion Concentration; Kinetics; Molecular Structure; Morpholines/chemical synthesis/*chemistry; Phthalic Acids/chemical synthesis/*chemistry; Temperature |
| Subjects: | Q Science > QD Chemistry |
| Divisions: | Faculty of Science > Department of Chemistry |
| Depositing User: | Miss Malisa Diana |
| Date Deposited: | 03 Jul 2013 07:01 |
| Last Modified: | 27 Aug 2019 06:09 |
| URI: | http://eprints.um.edu.my/id/eprint/8066 |
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