Ariffin, Azhar and Khan, M.N. (2003) Kinetics and mechanism of intramolecular Carboxylic Acid participation in the hydrolysis of N-Methoxyphthalamic Acid. Organic & Biomolecular Chemistry, 1 (8). pp. 1401-1408. DOI https://doi.org/10.1039/b300662j.
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Abstract
The rate of formation and disappearance of phthalic anhydride (PAn) intermediate in the aqueous cleavage of N-methoxyphthalamic acid (NMPA) under acidic pH was studied spectrophotometrically in mixed CH3CN-H2O solvents. The rate of formation of PAn from NMPA is almost independent of the change in acetonitrile content from 20 to 70% v/v in mixed aqueous solvents. The rate constants for the formation of PAn from NMPA are similar to10-fold smaller than the corresponding rate constants for the formation of PAn from o-carboxybenzohydroxamic acid (OCBA). These observations are ascribed to the consequence of the occurrence of slightly different mechanisms in these reactions.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Additional Information: | Department of Chemistry, Faculty of Science Building, University of Malaya, 50603 Kuala Lumpur, MALAYSIA |
| Uncontrolled Keywords: | Alkaline-Hydrolysis; Phthalic-Anhydride; Aqueous Cleavage; Primary Amines; Aminolysis; Catalysis; Model |
| Subjects: | Q Science > QD Chemistry |
| Divisions: | Faculty of Science > Department of Chemistry |
| Depositing User: | Miss Malisa Diana |
| Date Deposited: | 03 Jul 2013 09:17 |
| Last Modified: | 27 Aug 2019 06:08 |
| URI: | http://eprints.um.edu.my/id/eprint/8040 |
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