Claudin expression and tight junction protein localization in the lining epithelium of the keratocystic odontogenic tumors, dentigerous cysts, and radicular cysts

Siar, C.H. and Abbas, S.A. (2013) Claudin expression and tight junction protein localization in the lining epithelium of the keratocystic odontogenic tumors, dentigerous cysts, and radicular cysts. Oral Surgery Oral Medicine Oral Pathology Oral Radiology, 115 (5). pp. 652-659. ISSN 2212-4403

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Objective. The aim of this study was to evaluate the expression and localization of tight junction proteins (TJPs) or claudins in the keratocystic odontogenic tumor (KCOT) and to correlate with its biological behavior. Study Design. Five claudins (-1, -3, -4, -5, and 7) were examined immunohistochemically in 25 KCOTs and compared with 10 dentigerous cysts (DCs) and 10 radicular cysts (RCs). Results. Marked claudin-3 loss of expression in KCOT basal layer (n = 24/25; 96) compared with DCs (n = 1/10; 10) and RCs (n = 5/10; 50) (P < .05) suggests that claudin-3 downregulation may indicate altered or loss of basal cell polarity and impaired barrier function of KCOT lining epithelium and this might contribute indirectly to its biological behavior. In contrast, claudins-1, -4, -5, and -7 distribution patterns were less distinctive in all three entities, suggesting that these TJP molecules probably play limited roles in influencing their different growth potentials. Conclusion. Present findings suggest that differential claudin expressions in the lining epithelium of KCOTs, DCs, and RCs probably reflect their neoplastic or nonneoplastic nature.

Item Type: Article
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Uncontrolled Keywords: Squamous-cell; Carcinoma; Ameloblastomas; Occludin; Proliferation
Subjects: R Medicine > RK Dentistry
Divisions: Faculty of Dentistry > Dept of Oral Pathology & Oral Medicine & Periodontology
Depositing User: Mr Ahmad Azwan Azman
Date Deposited: 10 Jul 2013 02:52
Last Modified: 10 Jul 2013 02:52

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