Siar, C.H. and Abbas, S.A. (2013) Claudin expression and tight junction protein localization in the lining epithelium of the keratocystic odontogenic tumors, dentigerous cysts, and radicular cysts. Oral Surgery Oral Medicine Oral Pathology Oral Radiology, 115 (5). pp. 652-659. ISSN 2212-4403, DOI https://doi.org/10.1016/j.oooo.2013.02.013.
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Abstract
Objective. The aim of this study was to evaluate the expression and localization of tight junction proteins (TJPs) or claudins in the keratocystic odontogenic tumor (KCOT) and to correlate with its biological behavior. Study Design. Five claudins (-1, -3, -4, -5, and 7) were examined immunohistochemically in 25 KCOTs and compared with 10 dentigerous cysts (DCs) and 10 radicular cysts (RCs). Results. Marked claudin-3 loss of expression in KCOT basal layer (n = 24/25; 96) compared with DCs (n = 1/10; 10) and RCs (n = 5/10; 50) (P < .05) suggests that claudin-3 downregulation may indicate altered or loss of basal cell polarity and impaired barrier function of KCOT lining epithelium and this might contribute indirectly to its biological behavior. In contrast, claudins-1, -4, -5, and -7 distribution patterns were less distinctive in all three entities, suggesting that these TJP molecules probably play limited roles in influencing their different growth potentials. Conclusion. Present findings suggest that differential claudin expressions in the lining epithelium of KCOTs, DCs, and RCs probably reflect their neoplastic or nonneoplastic nature.
| Item Type: | Article |
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| Funders: | UNSPECIFIED |
| Additional Information: | ISI Document Delivery No.: 139PL Times Cited: 0 Cited Reference Count: 31 Cited References: Alaeddini M, 2009, ORAL DIS, V15, P422, DOI 10.1111/j.1601-0825.2009.01566.x Bello IO, 2007, J ORAL PATHOL MED, V36, P48 Bereket C, 2012, ORAL SURG ORAL MED O, DOI 10.1016/j.oooo.2012.02.029, DOI 10.1016/J.0000.2012.02.029 da Silva TA, 2008, ORAL SURG ORAL MED O, V105, P333, DOI 10.1016/j.tripleo.2007.06.009 de Oliveira Marcia Gaiger, 2011, Head Neck Pathol, V5, P1, DOI 10.1007/s12105-010-0216-0 EVERSOLE LR, 1975, CANCER, V35, P270, DOI 10.1002/1097-0142(197501)35:1<270::AID-CNCR2820350134>3.0.CO;2-Y Furuse M, 1998, J CELL BIOL, V141, P1539, DOI 10.1083/jcb.141.7.1539 Gonzalez-Mariscal L, 2003, PROG BIOPHYS MOL BIO, V81, P1, DOI 10.1016/S0079-6107(02)00037-8 Hakim SG, 2011, CLIN ORAL INVEST, V15, P321, DOI 10.1007/s00784-010-0388-8 Henriques ACG, 2011, ORAL SURG ORAL MED O, V112, P468, DOI 10.1016/j.tripleo.2011.05.033 Hoshino M, 2008, ORAL DIS, V14, P606, DOI 10.1111/j.1601-0825.2007.01427.x Jung JH, 2009, PATHOL RES PRACT, V205, P409, DOI 10.1016/j.prp.2008.12.015 Kichi E, 2005, J ORAL PATHOL MED, V34, P280, DOI 10.1111/j.1600-0714.2005.00314.x Kolar Z, 2006, J ORAL PATHOL MED, V35, P75, DOI 10.1111/j.1600-0714.2006.00382.x Mendes RA, 2011, ORAL SURG ORAL MED O, V111, P333, DOI 10.1016/j.tripleo.2010.10.004 Mitic LL, 1998, ANNU REV PHYSIOL, V60, P121, DOI 10.1146/annurev.physiol.60.1.121 Morita K, 1999, J CELL BIOL, V147, P185, DOI 10.1083/jcb.147.1.185 Okamoto E, 2010, J ORAL PATHOL MED, V39, P110, DOI 10.1111/j.1600-0714.2009.00851.x Oliveira SS, 2007, CELL MOL LIFE SCI, V64, P17, DOI 10.1007/s00018-006-6314-1 Philipsen HP, 2005, WHO CLASSIFICATION T, P306 Schneeberger EE, 2004, AM J PHYSIOL-CELL PH, V286, pC1213, DOI 10.1152/ajpcell.00558.2003 SIAR CH, 1987, INT J ORAL MAX SURG, V16, P95, DOI 10.1016/S0901-5027(87)80036-X SIAR CH, 1988, BRIT J ORAL MAX SURG, V26, P215, DOI 10.1016/0266-4356(88)90165-9 Soini Y, 2005, HISTOPATHOLOGY, V46, P551, DOI 10.1111/j.1365-2559.2005.02127.x Swisshelm K, 2005, ADV DRUG DELIVER REV, V57, P919, DOI 10.1016/j.addr.2005.01.006 Tokes AM, 2005, BREAST CANCER RES, V7, P296 Tsukita S, 2008, ONCOGENE, V27, P6930, DOI 10.1038/onc.2008.344 Tsuneki M, 2008, J ORAL PATHOL MED, V37, P287, DOI 10.1111/j.1600-0714.2007.00620.x Usami Y, 2006, HUM PATHOL, V37, P569, DOI 10.1016/j.humpath.2005.12.018 VANDERWAL KGH, 1993, INT J ORAL MAX SURG, V22, P350, DOI 10.1016/S0901-5027(05)80665-4 Wang YP, 2009, J FORMOS MED ASSOC, V108, P286, DOI 10.1016/S0929-6646(09)60068-1 Siar, Chong Huat Abbas, Syed Amjad University of Malaya PS018/2010A, RG471/12HTM This study was supported by the University of Malaya Postgraduate Research Grant (no. PS018/2010A) and University of Malaya Research Grant (RG471/12HTM). Elsevier science inc New york |
| Uncontrolled Keywords: | Squamous-cell; Carcinoma; Ameloblastomas; Occludin; Proliferation |
| Subjects: | R Medicine > RK Dentistry |
| Divisions: | Faculty of Dentistry > Dept of Oral Pathology & Oral Medicine & Periodontology |
| Depositing User: | Mr Ahmad Azwan Azman |
| Date Deposited: | 10 Jul 2013 02:52 |
| Last Modified: | 10 Jul 2013 02:52 |
| URI: | http://eprints.um.edu.my/id/eprint/7866 |
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