Tamamura, R. and Nagatsuka, H. and Siar, C.H. and Katase, N. and Naito, I. and Sado, Y. and Nagai, N. (2013) Comparative analysis of basal lamina type IV collagen alpha chains, matrix metalloproteinases-2 and-9 expressions in oral dysplasia and invasive carcinoma. Acta Histochemica, 115 (2). pp. 113-119. ISSN 0065-1281, DOI https://doi.org/10.1016/j.acthis.2012.05.001.
![[img]](http://eprints.um.edu.my/style/images/fileicons/application_pdf.png) |
PDF
comparative_analysis.pdf Restricted to Registered users only Download (1MB) | Request a copy |
![[img]](http://eprints.um.edu.my/style/images/fileicons/application_msword.png) |
Microsoft Word
Comparative_analysis_of_basal_lamina_type_IV_collagen_alpha_chains,_matrix_metalloproteinases-2_and-9_expressions_in_oral_dysplasia_and_invasive_carcinoma.docx Download (37kB) |
Abstract
The aim of this study was to compare the expressions of basal lamina (BL) collagen IV alpha chains and matrix metalloproteinases (MMP)-2 and MMP-9 in oral dysplasia (OED) and invasive carcinoma. Ten cases each of OEDs, carcinomas-in situ and oral squamous cell carcinomas (OSCCs) were examined by immunohistochemistry. Another 5 cases, each of normal and hyperplastic oral mucosa, served as controls. Results showed that alpha 1(IV)/alpha 2(IV) and alpha 5(IV)/alpha 6(IV) chains were intact in BLs of control and OEDs. In BLs of carcinoma-in situ, alpha 1(IV)/alpha 2(IV) chains preceded alpha 5(IV)/alpha 6(IV) chains in showing incipient signs of disruption. OSCCs exhibited varying degrees of collagen alpha(IV) chain degradation. MMP-2 and MMP-9 were absent in controls and OED, but weakly detectable in carcinoma-in situ. In OSCC, these proteolytic enzymes were expressed in areas corresponding to collagen alpha(IV) chain loss. Enzymatic activity was enhanced in higher grade OSCC, and along the tumor advancing front. Overall the present findings suggest that loss of BL collagen alpha(IV) chains coincided with gain of expression for MMP-2 and MMP-9, and that these protein alterations are crucial events during progression from OED to OSCC. (C) 2012 Elsevier GmbH. All rights reserved.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Additional Information: | ISI Document Delivery No.: 103QQ Times Cited: 0 Cited Reference Count: 40 Cited References: Barnes L, 2005, PATHOLOGY GENETICS H Barros SSLV, 2011, ARCH ORAL BIOL, V56, P752, DOI 10.1016/j.archoralbio.2010.11.022 Capo-Chi Chi CD, 2002, CANCER, V95, P1802 DAVIES B, 1993, CANCER RES, V53, P5365 DAVIES B, 1993, BRIT J CANCER, V67, P1126, DOI 10.1038/bjc.1993.207 de Vicente JC, 2005, ORAL ONCOL, V41, P283, DOI 10.1016/j.oraloncology.2004.08.013 Erickson AC, 2000, J HISTOCHEM CYTOCHEM, V48, P1291 Fleischmajer R, 1997, J INVEST DERMATOL, V109, P527, DOI 10.1111/1523-1747.ep12336696 Friedl P, 2003, NAT REV CANCER, V3, P362, DOI 10.1038/nrc1075 Garcia AS, 2006, MED ORAL PATOL ORAL, V11, pE100 GUSTERSON BA, 1984, LAB INVEST, V51, P82 HAMDY FC, 1994, BRIT J CANCER, V69, P177, DOI 10.1038/bjc.1994.30 Impola U, 2004, J PATHOL, V202, P14, DOI 10.1002/path.1479 Jordan RCK, 2004, CLIN CANCER RES, V10, P6460, DOI 10.1158/1078-0432.CCR-04-0656 Kadono G, 2004, PANCREAS, V29, P61, DOI 10.1097/00006676-200407000-00057 Kagawa M, 1997, NEPHROL DIAL TRANSPL, V12, P1238, DOI 10.1093/ndt/12.6.1238 Kale Alka D, 2012, J Oral Maxillofac Pathol, V16, P10 Kato K, 2005, J CANCER RES CLIN, V131, P340, DOI 10.1007/s00432-004-0654-8 Liabakk NB, 1996, CANCER RES, V56, P190 Misumi S, 2004, VIRCHOWS ARCH, V445, P54, DOI 10.1007/s00428-004-1015-3 Nagase H, 1999, J BIOL CHEM, V274, P21491, DOI 10.1074/jbc.274.31.21491 Nagatsuka H, 2005, VIRCHOWS ARCH, V447, P710, DOI 10.1007/s00428-005-0016-1 Nakano K, 2001, J PATHOL, V194, P420, DOI 10.1002/path.928 Nakano S, 1999, LAB INVEST, V79, P281 NINOMIYA Y, 1995, J CELL BIOL, V130, P1219, DOI 10.1083/jcb.130.5.1219 Patel BP, 2005, J SURG ONCOL, V90, P81, DOI 10.1002/jso.20240 Qiao B, 2010, INT J ONCOL, V37, P663, DOI 10.3892/ijo₀₀₀₀₀₇₁₅ Redondo P, 2005, CLIN EXP DERMATOL, V30, P541, DOI 10.1111/j.1365-2230.2005.01849.x SADO Y, 1995, HISTOCHEM CELL BIOL, V104, P267, DOI 10.1007/BF01464322 Seki Y, 1998, HISTOCHEM CELL BIOL, V110, P359 Skovbjerg H, 2009, BMC CANCER, V9, DOI 10.1186/1471-2407-9-136 Sutinen M, 1998, BRIT J CANCER, V77, P2239, DOI 10.1038/bjc.1998.372 Tamamura R, 2006, VIRCHOWS ARCH, V449, P358, DOI 10.1007/s00428-006-0260-z Tanaka K, 1997, HISTOCHEM J, V29, P563, DOI 10.1023/A:1026428010104 WOESSNER JF, 1991, FASEB J, V5, P2145 Woodhouse EC, 1997, CANCER, V80, P1529, DOI 10.1002/(SICI)1097-0142(19971015)80:8+<1529::AID-CNCR2>3.3.CO;2-# YURCHENCO PD, 1994, CURR OPIN CELL BIOL, V6, P674, DOI 10.1016/0955-0674(94)90093-0 Zargaran M, 2011, J ORAL PATHOL MED, V40, P167, DOI 10.1111/j.1600-0714.2010.00983.x Zeng ZS, 1999, CARCINOGENESIS, V20, P749, DOI 10.1093/carcin/20.5.749 Zhou CX, 2010, AUST DENT J, V55, P385, DOI 10.1111/j.1834-7819.2010.01258.x Tamamura, Ryo Nagatsuka, Hitoshi Siar, Chong Huat Katase, Naoki Naito, Ichiro Sado, Yoshikazu Nagai, Noriyuki Japanese Ministry of Education, Culture, Sports, Science and Technology 24592766; University of Malaya RG394/11HTM This study was supported by the Japanese Ministry of Education, Culture, Sports, Science and Technology (C) 24592766 and the University of Malaya RG394/11HTM. Elsevier gmbh, urban & fischer verlag Jena |
| Uncontrolled Keywords: | Basal lamina Collagen IV alpha chains MMP-2 and-9 Epithelial dysplasia Carcinoma-in situ Oral squamous cell carcinoma Human squamous-cell carcinoma defined monoclonal-antibodies basement-membrane differential expression messenger-rna colorectal-cancer mmp-9 matrix-metalloproteinase-9 localization alpha-5(iv) |
| Subjects: | R Medicine > RK Dentistry |
| Divisions: | Faculty of Dentistry > Dept of Oral Pathology & Oral Medicine & Periodontology |
| Depositing User: | Mr Ahmad Azwan Azman |
| Date Deposited: | 17 Jul 2013 00:09 |
| Last Modified: | 17 Jul 2013 00:09 |
| URI: | http://eprints.um.edu.my/id/eprint/7735 |
Actions (login required)
 |
View Item |
