Nephrotoxicity of hump-nosed pit viper (Hypnale hypnale) venom in mice is preventable by the paraspecific Hemato polyvalent antivenom (HPA)

Tan, C.H. and Tan, N.H. and Sim, S.M. and Fung, S.Y. and Jayalakshmi, P. and Gnanathasan, C.A. (2012) Nephrotoxicity of hump-nosed pit viper (Hypnale hypnale) venom in mice is preventable by the paraspecific Hemato polyvalent antivenom (HPA). Toxicon, 60 (7). pp. 1259-1262. ISSN 0041-0101

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Official URL: http://www.sciencedirect.com/science/article/pii/S...

Abstract

Mice experimentally envenomed with Hypnale hypnale venom (1 x and 1.5x LD50) developed acute kidney injury (AKI) principally characterized by raised blood urea and creatinine. Prolonged blood clotting time and hemorrhage in lungs implied bleeding tendency. Pallor noted in most renal cortices was suggestive of renal ischemia secondary to consumptive coagulopathy. Intravenous infusion of Hemato polyvalent antivenom following experimental envenoming effectively prevented death and AKI in all mice, supporting its potential therapeutic use in envenoming cases. (C) 2012 Elsevier Ltd. All rights reserved.

Item Type: Article
Additional Information: Tan, Choo Hock Tan, Nget Hong Sim, Si Mui Fung, Shin Yee Jayalakshmi, Pailoor Gnanathasan, Christeine Ariaranee
Uncontrolled Keywords: Hypnale hypnale; Venom; Nephrotoxicity; Acute kidney injury; Polyvalent antivenom
Subjects: R Medicine
Divisions: Faculty of Medicine
Depositing User: Ms Haslinda Lahuddin
Date Deposited: 22 Jul 2013 01:31
Last Modified: 22 Jul 2013 01:31
URI: http://eprints.um.edu.my/id/eprint/7672

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