Antimalarial activity of extracts of Malaysian medicinal plants

Rahman, N.N.N.A. and Furuta, T. and Kojima, S. and Takane, K. and Ali Mohd, M. (1999) Antimalarial activity of extracts of Malaysian medicinal plants. Journal of Ethnopharmacology, 64 (3). pp. 249-254. ISSN 0378-8741

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Abstract

In vitro and in vivo studies revealed that Malaysian medicinal plants, Piper sarmentosum, Andrographis paniculata and Tinospora crispa produced considerable antimalarial effects. Chloroform extract in vitro did show better effect than the methanol extract. The chloroform extract showed complete parasite growth inhibition as low as 0.05 mg/ml drug dose within 24 h incubation period (Andrographis paniculata) as compared to methanol extract of drug dose of 2.5 mg/ml but under incubation time of 48 h of the same plant spesies. In vivo activity of Andrographis paniculata also demonstrated higher antimalarial effect than other two plant species. (C) 1999 Published by Elsevier Science Ireland Ltd. All rights reserved.

Item Type: Article
Additional Information: Times Cited: 31 Rahman, NNNA Furuta, T Kojima, S Takane, K Ali Mohd, M
Uncontrolled Keywords: Piper sarmentosum; Andrographispaniculata; Tinospora crispa; Plasmodium falciparum; Plasmodium berghei; Antimalarial
Subjects: R Medicine
Divisions: Faculty of Medicine
Depositing User: Ms Haslinda Lahuddin
Date Deposited: 12 Aug 2013 00:59
Last Modified: 12 Aug 2013 00:59
URI: http://eprints.um.edu.my/id/eprint/7647

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