Assessment of pubertal development in juvenile male rats after sub-acute exposure to bisphenol A and nonylphenol

Tan, B.L.L. and Kassim, N.M. and Mohd, M.A. (2003) Assessment of pubertal development in juvenile male rats after sub-acute exposure to bisphenol A and nonylphenol. Toxicology Letters, 143 (3). pp. 261-270. ISSN 0378-4274, DOI https://doi.org/10.1016/s0378-4274(03)00172-3.

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Abstract

The effects of bisphenol A and nonylphenol on pubertal development in the intact juvenile/peripubertal male Sprague-Dawley rats was observed in this study from PND23-52/53. Two groups of rats were administered orally with either 100 mg/kg body weight of nonylphenol or bisphenol A. Another group of rats were administered orally with a mixture of 100 mg/kg body weight of nonylphenol and bisphenol A. Control group was administered with the vehicle of Tween-80 with corn oil (1:9 v/v). Observations made in this study included growth, age at preputial separation, thyroid, liver, testis and kidney weight and histology, epididymal and seminal vesicle plus coagulation gland weight. Nonylphenol and bisphenol A have been observed to cause delay in puberty onset as well as testicular damage in the treatment groups when compared to the control; spermatogenesis was affected in most treated rats. Bisphenol A also caused the enlargement of the kidney and hydronephrosis. Administration of nonylphenol and bisphenol A as a mixture has caused less than additive effects. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.

Item Type:	Article
Funders:	UNSPECIFIED
Additional Information:	Times Cited: 33 Tan, BLL Kassim, NM Mohd, MA
Uncontrolled Keywords:	Nonylphenol; Bisphenol A; Endocrine-disrupting chemicals; Environmental pollutant; Pubertal assay; Spermatogenesis; Estrogenic
Subjects:	R Medicine
Divisions:	Faculty of Medicine
Depositing User:	Ms Haslinda Lahuddin
Date Deposited:	12 Aug 2013 03:34
Last Modified:	12 Aug 2013 03:34
URI:	http://eprints.um.edu.my/id/eprint/7629

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