Screening for hypoglycemic activity on the leaf extracts of nine medicinal plants: in-vivo evaluation

Arya, A. and Abdullah, M.A. and Haerian, B.S. and Mohd, M.A. (2012) Screening for hypoglycemic activity on the leaf extracts of nine medicinal plants: in-vivo evaluation. E-Journal of Chemistry, 9 (3). pp. 1196-1205. ISSN 0973-4945,

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Abstract

The traditional use of certain plants by the tribal community in central India involves using the young leaves for several ailments, including hyperglycaemia; this study was performed to evaluate the effects of the leaf extracts from 9 such plants in the management of diabetes. Initially, hypoglycemic screening was performed on normal rats whose blood glucose levels were measured before and after oral or intraperitoneal (i.p.) administration of the extracts at different periods. The plants were screened at doses of 250 mg/kg i.p. or 500 mg/kg orally. Of these, only Centratherum anthelminticum (Asteraceae), Cissus quadrangularis (Vitaceae), and Woodfordia fruticosa Kurz (Lythraceae) significantly reduced postprandial blood glucose levels in normal glycemic rats (P < 0.001), with slight reductions effected by Sida acuta Burm F. (P = 0.002) and Parthenium hysterophorus L. (P = 0.017). The extracts that reduced postprandial blood glucose levels both orally and i.p. in the hypoglycemic screening tests were evaluated for glucose challenge in glucose tolerance tests with i.p and oral administration in overnight-fasted normal rats. The results of these tests potentiate the screening data in the management of diabetes mellitus, which requires further studies on the plants that yielded positive results to determine the active compounds in the different plant parts that are responsible for the activity.

Item Type:	Article
Funders:	UNSPECIFIED
Additional Information:	Times Cited: 1 Arya, Aditya Abdullah, Mahmood Ameen Haerian, Batoul Sadat Mohd, Mustafa Ali
Uncontrolled Keywords:	Hypoglycemic activity, Traditional medicine, Herbals, Glucose tolerance test,Centratherum anthelminticum, Cissus quadrangularis, Woodfordia fruticosa.
Subjects:	R Medicine
Divisions:	Faculty of Medicine
Depositing User:	Ms Haslinda Lahuddin
Date Deposited:	05 Aug 2013 01:34
Last Modified:	05 Aug 2013 01:34
URI:	http://eprints.um.edu.my/id/eprint/7592

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