Effects of soya bean extract, bisphenol A and 17 beta-estradiol on the testis and circulating levels of testosterone and estradiol among peripubertal juvenile male sprague-dawley rats

Norazit, A. and Mohamad, J. and Razak, S.A. and Abdulla, M.A. and Azmil, A. and Mohd, M.A. (2012) Effects of soya bean extract, bisphenol A and 17 beta-estradiol on the testis and circulating levels of testosterone and estradiol among peripubertal juvenile male sprague-dawley rats. Sains Malaysiana, 41 (1). pp. 63-69. ISSN 0126-6039

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Abstract

In this study, juvenile male Sprague-Dawley rats (PND 22) were fed with soya extract, bisphenol A, and 17 beta-estradiol, respectively by oral gavage to determine the potential effect on the morphology of their reproductive organs and their hormonal levels. After three weeks of treatment (PND 43), all animals were sacrificed and the blood and testes were collected. All the three treatment groups showed histological differences in testes morphology compared to the control. Animals treated with soya extract and bisphenol A showed a decrease in circulating estradiol levels while animals treated with 17 beta-estradiol showed elevated circulating levels of estradiol. Only the animals treated with soya extract showed elevated levels of circulating testosterone. The results of the present study showed that, soya extract, bisphenol A, and 17 beta-estradiol can alter the histological structure of the testes and influence circulating steroidal hormone levels.

Item Type: Article
Additional Information: Times Cited: 0 Norazit, Anwar Mohamad, Jamaludin Razak, Shaharudin Abdul Abdulla, Mahmood Ameen Azmil, Ashriya Mohd, Mustafa Ali
Uncontrolled Keywords: 17β-estradiol; Bisfenol A; Fitoestrogen; Hormon Steroid; Sistem Pembiakan
Subjects: R Medicine
Divisions: Faculty of Medicine
Depositing User: Ms Haslinda Lahuddin
Date Deposited: 01 Aug 2013 01:50
Last Modified: 19 Mar 2019 08:47
URI: http://eprints.um.edu.my/id/eprint/7580

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