Khor, C.S. and Sam, I.C. and Hooi, P.S. and Chan, Yoke Fun (2013) Displacement of predominant respiratory syncytial virus genotypes in Malaysia between 1989-2011. Infection, Genetics and Evolution, 14. pp. 357-360. ISSN 1567-1348,
Full text not available from this repository.Abstract
From 1989 to 2011 in Kuala Lumpur, Malaysia, multiple genotypes from both respiratory syncytial virus (RSV) subgroups were found co-circulating each year. RSV-A subgroup predominated in 12 out of 17 years with the remaining years predominated by RSV-B subgroup. Local RSV strains exhibited temporal clustering with RSV strains reported in previous epidemiological studies. Every few years, the existing predominant genotype was replaced by a new genotype. The RSV-A genotypes GA2, GA5 and GA7 were replaced by NA1 and NA2, while BA became the predominant RSV-B genotype. A unique local cluster, BA12, was seen in 2009, and the recently-described ON1 genotype with 72-nt duplication emerged in 2011. Our findings will have important implications for future vaccine intervention.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | Human respiratory syncytial virus; Molecular epidemiology; Genotype; Malaysia |
| Subjects: | R Medicine |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms azrahani halim |
| Date Deposited: | 15 Jul 2013 01:41 |
| Last Modified: | 07 May 2019 08:14 |
| URI: | http://eprints.um.edu.my/id/eprint/7270 |
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