Autoimmune markers in young Malaysian patients with type 1 diabetes mellitus

Nazaimoon, W.M.; Azmi, K.N.; Rasat, R.; Ismail, I.S.; Singaraveloo, M.; Mohamad, W.B.; Letchuman, R.; Sheriff, I.H.; Faridah, I.; Khalid, B.A. (2000) Autoimmune markers in young Malaysian patients with type 1 diabetes mellitus. Medical Journal of Malaysia, 55 (3). pp. 318-323. ISSN 0300-5283

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Abstract

This study determined the prevalence and significance of autoantibodies to GAD65 (GAD Ab), insulin (IAA), tyrosine-like phosphatase (IA2) and islet-cell (ICA) in a group of 213 young Malaysian Type 1 diabetics, diagnosed before the age of 40 years. Venous blood was taken at fasting, and at 6 minutes post-glucagon (1 mg i.v.). IAA was detected in 47.4, GAD Ab in 33.8, IA2 in 8.9 and ICA in 1.4 of the subjects. When based on post-glucagon C-peptide level of 600 pmol/L, 172 (80.7) patients had inadequate pancreatic reserve, while the remainder 41(19.3) showed normal response. The autoantibodies, either alone or in combination, were detectable in both groups of patients; higher prevalence in those with poor or no beta-cell function (73.3 versus 46.3, p = 0.0001). Although the prevalence of GAD Ab was highest in newly diagnosed patients (< 5 years), unlike IA2 and ICA, the marker remained detectable in 24-25 of those patients with long-standing disease. Nineteen patients could probably belong to the "latent autoimmune diabetes in adults (LADA)" subset, where pancreatic reserve was adequate but patients had detectable autoantibodies and insulin-requiring. On the other hand, 68 of the 213 patients (32) were seronegative, but presented with near or total beta-cell destruction. Thus, as has also been suggested by others, there is indeed etiological differences between the Asian and the Caucasian Type 1 diabetics, and, there is also the possibility that other, but unknown autoantigens are involved in causing the pancreatic damage.

Item Type: Article
Creators:
  1. Nazaimoon, W.M.
  2. Azmi, K.N.
  3. Rasat, R.
  4. Ismail, I.S.(Department of Medicine, Faculty of Medicine Building, University of Malaya, 50603 Kuala Lumpur, MALAYSIA)
  5. Singaraveloo, M.
  6. Mohamad, W.B.
  7. Letchuman, R.
  8. Sheriff, I.H.
  9. Faridah, I.
  10. Khalid, B.A.
Journal or Publication Title: Medical Journal of Malaysia
Additional Information: Cited By (since 1996):5 Export Date: 23 April 2013 Source: Scopus PubMed ID: 11200711 Language of Original Document: English Correspondence Address: Nazaimoon, W.M. : Chemicals/CASAutoantibodies; GAD65 enzyme, EC 4.1.1.-; Glutamate Decarboxylase, EC 4.1.1.15; Insulin, 11061-68-0; Isoenzymes; Protein-Tyrosine-Phosphatase, EC 3.1.3.48
Subjects: R Medicine
Divisions: Faculty of Medicine
Depositing User: Ms Haslinda Lahuddin
Date Deposited: 12 Jul 2013 09:48
Last Modified: 10 Dec 2013 12:45
URI: http://eprints.um.edu.my/id/eprint/7230

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