Leong, W.F. and Cheong, K.W. and Lai, O.M. and Long, K. and Man, Y.B.C. and Misran, Misni and Tan, C.P. (2011) Response surface modeling of processing parameters for the preparation of phytosterol nanodispersions using an emulsification-evaporation technique. Journal of the American Oil Chemists' Society, 88 (5). pp. 717-725. ISSN 0003-021X, DOI https://doi.org/10.1007/s11746-010-1714-7.
Full text not available from this repository.Abstract
The purpose of this study was to optimize the production parameters for water-soluble phytosterol nanodispersions. Response surface methodology (RSM) was employed to model and optimize three of the processing parameters: mixing time (t) by conventional homogenizer (1-20 min), mixing speed (v) by conventional homogenizer (1,000-9,000 rpm) and homogenization pressure (P) by high-pressure homogenizer (0.1-80 MPa). All responses i.e., mean particle size (PS), polydispersity index (PDI) and phytosterols concentration (Phyto, mg/l) fitted well to a reduced quadratic model by multiple regressions after manual elimination. For PS, PDI and Phyto, the coefficients of determination (R 2) were 0.9902, 0.9065 and 0.8878, respectively. The optimized processing parameters were 15.25 min mixing time, 7,000 rpm mixing speed and homogenization pressure 42.4 MPa. In the produced nanodispersions, the corresponding responses for the optimized preparation conditions were a PS of 52 nm, PDI of 0.3390 and a Phyto of 336 mg/l.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | High-pressure Nanodispersion Phytosterol Response surface methodology High-pressure homogenizers Homogenizers Mean particle size Mixing speed Mixing time Multiple regressions Nano-dispersions Polydispersity indices Preparation conditions Processing parameters Production parameters Quadratic models Response surface modeling Emulsification Mixing Optimization Polydispersity Surface properties |
| Subjects: | Q Science > QD Chemistry |
| Divisions: | Faculty of Science > Department of Chemistry |
| Depositing User: | miss munirah saadom |
| Date Deposited: | 08 Jul 2013 08:43 |
| Last Modified: | 16 Apr 2019 03:30 |
| URI: | http://eprints.um.edu.my/id/eprint/6856 |
Actions (login required)
 |
View Item |
